Synthesis and Anti‐inflammatory Activity of Some 1‐Methyl‐5‐(4‐substituted benzoyl)imidazole‐2‐acetates

Pharmacy and Pharmacology Communications 02/2010; 5(4):273 - 275. DOI: 10.1211/146080899128734839


1-Methyl-5-(4-X-benzoyl)imidazole-2-acetates were synthesized and tested for anti-inflammatory activity. Tolmetin and aspirin were used as reference drugs.The most active compound against carrageenan-induced oedema in rat hindpaw was a 4-chlorobenzoyl derivative, which was almost 1–5-times more active than the reference drug aspirin. In addition, it had half the activity of tolmetin.

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Available from: Saghar Kaabinejadian, Dec 09, 2014
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