Three different deep-seawater (DSW) treated by means of reverse osmosis (RO DSW), electrodialysis (ED DSW) and 10% (v/v) dilution with ddH2O (10% DSW) were as treated groups, while distilled water (NDW) was the control group. Body weight changes, feed and water intakes of high-cholesterol dietary mice were not (P < 0.05) influenced by drinking different waters. Although drinking ED and 10% DSW lowered (P < 0.05) serum cholesterol, triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) levels than NDW, the HDL-C/non-HDL-C ratio was only improved (P < 0.05) in the ED DSW group. These hypolipidemic effects of ED and 10% DSW might result from more (P < 0.05) fecal cholesterol/TG outputs compared with NDW and RO DSW groups. The rich K+ and Mg2+ contents, as well as better Mg2+/Ca2+ ratios in ED and 10% DSWs may counteract increased blood pressures of high-cholesterol dietary mice due to a higher hypertensive mineral, Na+.
Deep-seawater (DSW) was announced to own several health benefits commercially. However, only few researches were available, and the results were inconsistent. Because DSW is rich in minerals which result in high hardness, DSW is necessary to be treated by means of reverse osmosis (RO DSW) and electrodialysis (ED DSW) technologies, and 10% (v/v) dilution (10% DSW). This study aims to investigate the effects of three treated DSW (RO DSW, ED DSW and 10% DSW) on blood lipids and pressures in high-cholesterol dietary mice. Our results demonstrated that ED DSW showed the cardiovascular health effects, such as hindrances of the dietary-induced evaluation of total cholesterol, triglyceride and non-high-density lipoprotein cholesterol (non-HDL-C), as well as improvement of HDL-C/non-HDL-C ratio, when compared with RO and 10% DSW. Therefore, ED DSW might be suggested as an ingredient of hypolipidemic health food in some niche markets.