Iris coloboma managed with a prosthetic contact lens: A case report and review

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Coloboma of the iris is a relatively uncommon congenital condition seen in optometric practice. Symptoms include photophobia, greater chromatic and spherical aberration, reduced depth of focus, and poor cosmesis. A case is reported of a prosthetic (cosmetic) contact lens used in the alleviation of these symptoms.

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This new edition of a general textbook of ophthalmology, published four years after the previous edition, attests to its value and acceptance. Because of the vast amount of basic and new information in ophthalmology, there are few such textbooks written by a single author. In the preface, Newell acknowledges one solution to this problem, namely, to have his residents in ophthalmology read over assigned portions of the previous edition to suggest revision or additions. The general format and sections of the previous edition are retained, and there are 68 fewer pages and 140 fewer black and white illustrations. There has been a general condensation, with less space devoted to anatomy, embryology, basic mechanisms, uvea, and retina. The many elaborate tables and diagnostic charts of the previous edition are retained. The underlying basic science aspects of ocular physiology, pharmacology, and disease are particularly outstanding, eg, hereditary disorders and endocrine diseases. Many
A boy was born with multiple malformations including anencephaly with ectopic placenta, absent left arm, cleft lip and palate, syndactyly, coloboma of the iris, cataract and corneal opacity with vascularization. The mother had used lysergic acid diethylamide (LSD) before and during pregnancy. The limb amputation deformities are the primary findings in this case. These changes are sufficiently specific to suggest a correlation with other reported cases in which a higher than expected incidence of such deformities are observed in infants following maternal ingestion of the drug. This is only the second recorded case of lens abnormalities associated with maternal LSD ingestion.
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