This thesis describes a set of target holders that were designed for the production of positron emitting isotopes, using an 11 MeV, proton only, negative hydrogen ion cyclotron. The majority of these target holders (/sup 13/N, /sup 15/O and /sup 18/F) make efficient use of expensive, isotopically enriched target materials (/sup 13/C, /sup 15/N and /sup 18/O), allowing economical production of the
... [Show full abstract] various radioisotopes. Also described is a general purpose chemistry process control unit (CPCU) that allows the automated synthesis of a variety of positron-emitter labeled pharmaceuticals. The CPCU has been applied to the routine production of 2-(/sup 18/F)-fluoro-2-deoxy-D-glucose (FDG) as well as the synthesis of other radiolabeled compounds. The results described do not guarantee success for Clinical PET, but are a proof of principle. An 11 MeV, proton only cyclotron is sufficient to produce positron-emitting radionuclides for Clinical PET.