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Chemistry Applied to Iodine Radionuclides

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Abstract

IntroductionNuclear Medicine ApplicationsSpecific Radioisotopes of IodineApproaches to Radiolabeling with Isotopes of IodineExcitation Labeling ProceduresHalogen Exchange LabelingIodination Reactions Utilizing Chemical Oxidizing ReagentsRegio-specific Reactions with RadioiodineRadioiodination via OrganoboranesRadioiodination via OrganostannanesRadioiodination via Other Demetallation ReactionsStructural Integrity of Radioiodinated CompoundsConclusion References

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... The peptides H-LQLQPFPQPELPYP-QPELPYPQPELPYPQPQPF-OHY (33-mer) and H-LGQ-QQPFPPQQPYPQPQPF-OHY (19-mer), 98% pure (Schafer-N, Denmark), were 3 H-labeled in the underlined positions using diiodotyrosine (Y(3,5-I 2 )) iodinated peptides by standard technique [22,23]. They were dissolved in DMSO, mixed with 10% palladium on carbon catalyst, and subjected to 10 Ci tritium gas in a tritium manifold system (RC Tritec) for 2 h at room temperature, then purified by HPLC, and conserved by addition of 50 mM ascorbic acid. ...
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... The direct labelling of peptides and proteins with radioiodine (I-125) is currently one of the first choices because it can be done fast and easily and the chemistry is well developed. 5 However, introducing iodine into a peptide backbone may interfere with both the biological behaviour and stability of the peptide, 6 making tritium a more desirable radioisotope because it can be incorporated in stable positions and is an isotope of hydrogen. ...
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... Whenever possible, references from the last 10 years will be used. The author would apologize to those whose work has not been presented in this review, and for the omission of 18 F-labeled and iodinated biomolecules as diagnostic and therapeutic radiotracers, details of which can be found in recent review articles [15,16,20,21,69,70]. ...
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The Side Effects of Drugs Annuals forms a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The review of the January 2013 to June 2014 publications on adverse reactions to thyroid hormones, iodine and antithyroid drugs (ATDs) covers levothyroxine, the thyroid hormone analogue eprotirome, iodine and radioactive iodine and thionamides ATDs.
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