Central nervous system (CNS) depressant and Analgesic activity of methanolic extracts ofNardostachys jatamansi DC. and Coscinium fenestratum Colebr. in experimental animal model

Journal of Pharmacy Research 12/2009; 2(2):1716-1719.


The present study was conducted to investigate the analgesic and CNS depressant property of methanol extracts of Nardostachys jatamansi DC and Coscinium fenestratum Colebr in animal model. The analgesic activity of methanol extracts was evaluated by Tail flick method. CNS depressant activity was determined using digital Actophotometer. Phytoconstituents namely phenols, alkaloids, steroids, flavonoids and glycosides were present in both the extracts. In analgesic activity, the reaction time increased significantly for the extract and standard groups when compared to the predrug treatment. The locomotor activity count in the extract and standard drug treated group was significantly reduced when compared to control group. The analgesic and CNS depressant activity of extracts was found to be more than that of the standard drug. Further studies are needed to isolate the active constituents responsible for the observed effect and to reveal the possible mechanisms of action responsible for the analgesic and CNS activity.

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