Peripheral blood progenitor cell collections in multiple myeloma: Predictors and management of inadequate collections

ArticleinBritish Journal of Haematology 93(1):142 - 145 · October 2003with8 Reads
Impact Factor: 4.71 · DOI: 10.1046/j.1365-2141.1996.448987.x

    Abstract

    Thirty-seven patients with previously treated multiple myeloma (MM) underwent peripheral blood progenitor cell (PBPC) collection following high-dose cyclophosphamide and GM-CSF or sequential IL-3 and GM-CSF. Patients with an inadequate collection were considered for a second or third collection. 25 patients underwent subsequent autotransplant. The only variable predictive of CFU-GM yield was the extent of prior melphalan therapy. All repeat collections were unsuccessful and patients infused with an autograft obtained from multiple sets of collections had a high incidence of delayed engraftment. We conclude that melphalan should be avoided or PBPC collection performed early in the disease course in patients who are potential transplant candidates.