The Integrative Biology of Reproductive Functioning in Nonhuman Primates

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
American Journal of Primatology (Impact Factor: 2.44). 03/2013; 75(3). DOI: 10.1002/ajp.22054
Source: PubMed


At the 34th annual meeting of the American Society of Primatologists in 2011, the society organized an interdisciplinary symposium entitled, "Reproductive Function & Dysfunction in Nonhuman Primates." The five articles in this special issue, excluding this introduction, represent the findings presented by each of the five speakers in that symposium. The data presented highlight the myriad factors that contribute to primate reproductive function and dysfunction, including hormones, genes, maternal variance, environmental factors, social relationships, and strategic interactions. Collectively, these articles emphasize the integrative nature of primate reproductive function, and highlight the importance of the nonhuman primate as a model for human reproductive function and dysfunction in humans. Am. J. Primatol. 00:1-5, 2012. © 2012 Wiley Periodicals, Inc.

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    ABSTRACT: Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity-yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research. Am. J. Primatol. © 2014 Wiley Periodicals, Inc.
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