Article

Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: Invasive LVP measurements versus the QA interval

Bio-Plus Safety Pharmacology, Vlasmeer 5/0003, B-2400 Mol, Belgium.
Journal of pharmacological and toxicological methods (Impact Factor: 2.39). 07/2012; 66(2):152-9. DOI: 10.1016/j.vascn.2012.07.002
Source: PubMed

ABSTRACT

Evaluation of drug-related effects on cardiovascular function is part of the core battery described in the ICH S7A guideline. Anesthetized guinea-pigs are excellent models for the evaluation of drug-induced prolongation of ventricular repolarization; however less information is available regarding other cardio-hemodynamic parameters in this model. The current study aimed to document cardio-hemodynamic responses in anesthetized guinea-pigs after administration of a number of reference drugs with known pharmacological actions.

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