Comparison of calculations to estimate gastric emptying half-time of solids in humans

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, College of Medicine, Rochester, MN, USA Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, College of Medicine, Rochester, MN, USA.
Neurogastroenterology and Motility (Impact Factor: 3.59). 07/2012; 24(12). DOI: 10.1111/j.1365-2982.2012.01982.x
Source: PubMed


Background Measuring solid gastric emptying (GE) at 4 h is used to identify gastroparesis. GE half-time (GE T1/2) is useful to assess overall and early GE.
Aim To examine the validity of hourly imaging as a measurement of GE T1/2 compared with estimates from more detailed imaging.
Methods 155 human subjects (99 female, 56 male) underwent scintigraphic GE of a solid–liquid meal. We calculated the GE T1/2 using linear interpolation based on a full set of abdominal images obtained over 4 h, and the GE T1/2 based on images at 1, 2, 3, and 4 h after the meal with interpolation of data.
Key Results Differences in GE T1/2 values (entire set of scan times compared with just the hourly scans) were small [overall median (5th, 95th percentiles) = −0.2[−7.5, 4.6] min] with slightly greater differences in males compared with females. The agreement between the two methods was very high [concordance correlation coefficient (CCC) (95% CI) = 0.993 (0.990, 0.995)] and a Bland–Altman plot indicated the variation in the results between the two methods did not change appreciably across the range of GE studied (within ±10 min for all but four subjects). Calculated GE T1/2 values, omitting the 3-h data from the hourly measurements, were associated with similar high accuracy overall and for fast GE, but were less accurate with slow GE.
Conclusions & Inferences Results of GE T1/2 solids, using hourly imaging over 4 h, are accurate in the range 75–235 min which reflects the typical range of GE of solids in health and disease.

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