Profiling Plasma Peptides for the Identification of Potential Ageing Biomarkers in Chinese Han Adults

School of Public Health and Family Medicine, Capital Medical University, Beijing, People's Republic of China.
PLoS ONE (Impact Factor: 3.23). 07/2012; 7(7):e39726. DOI: 10.1371/journal.pone.0039726
Source: PubMed


Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.

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    • "It is also well recognized that biomarkers which may play important roles in physiologic and pathologic processes are important for diagnosis, prognosis, and prediction of HCC. Human serum contains LMW protein/peptides, which could be used as biomarker candidates,such as fibrinogen α-chain fibrinogen alpha, albumin and apolipoprotein A1 [27,28]. "
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