Fluphenazine and social therapy in the aftercare of schizophrenic patients. Relapse analyses of a two-year controlled study of fluphenazine decanoate and fluphenazine hydrochloride

ArticleinArchives of General Psychiatry 36(12):1283-94 · December 1979with22 Reads
Source: PubMed
Abstract
The ability of long-acting fluphenazine decanoate and oral fluphenazine hydrochloride to forestall relapse among newly discharge schizophrenic patients is examined in the context of high and low degrees of social therapy (ST). A total of 105 patients were randomly assigned to the various treatments and maintained under controlled conditions for two years or until relapse. Relapse rates for all treatments remained traditionally high. Relpase rates for long-acting fluphenazine decanoate and oral fluphenazine hydrochloride are nearly identical in the first year, indicating that drug noncompliance does not adequately explain early schizophrenic relapse. However, patients who received long-acting fluphenazine decanoate and ST have a reduced risk of relapse over time. Relapsers who received long-acting fluphenazine decanoate appeared more affectively disturbed than other relapsers, yet both groups were diagnostically and symptomatically equivalent prior to treatment. Personal discomfort and intrafamilial stress are important predictors.
    • "LAI antipsychotics were introduced for reasons of potential advantages compared to oral antipsychotics, including their ability to improve compliance and to distinguish between nonadherence and lack of response, to monitor the regular contact between patient and their caregivers, to reduce the risk of accidental or deliberate overdose, and to achieve better bioavailability in obtaining a more predictable correlation between drug dosage and plasma concentrations [70]. In the study of Hogarty et al. (1979), comparison of oral and LAI fluphenazine, demonstrated that relapse rates were notably worse for patients taking the oral formulation, but this was not apparent until after at least a year of treatment [71]. In the observational community cohort study in Finland [72], the administration of depot AP1G and LAI-risperidone resulted in reduction of the risk of rehospitalization by 50% or 65%, respectively, compared with oral formulations of the same antipsychotics. "
    Full-text · Chapter · Jan 2016 · PLoS ONE
    • "The Social Functioning Scale (SFS) was developed to assess social skills and performance, and to cover functions that are of importance for patients suffering from schizophrenia. Therefore, the SFS reflects the areas focused on in various psychosocial intervention programs222324 as well as the disabilities and the impairments assessed by the Disability Assessment Schedule [25]. The SFS represents both strengths and weaknesses of the patients in order to facilitate the planning of interventions and individual goals [11]. "
    [Show description] [Hide description] DESCRIPTION: Deficits in social functioning are a core symptom of schizophrenia and an important criterion for evaluating the success of treatment. However, there is little agreement regarding its measurement. A common, often cited instrument for assessing self-reported social functioning is the Social Functioning Scale (SFS). The study aimed to investigate the reliability and validity of the German translation. 101 patients suffering from schizophrenia (SZ) and 101 matched controls (C) (60 male / 41 female, 35.8 years in both groups) completed the German version. In addition, demographic, clinical, and functional data were collected. Internal consistency was investigated calculating Cronbach’s alpha for SFS full scale (α: .81) and all subscales (α: .59-.88). Significant bivariate correlation coefficients were found between all subscales as well as between all subscales and full scale (p <.01). For the total sample, principal component analysis gave evidence to prefer a single-factor solution (eigenvalue ≥ 1) accounting for 48.5 % of the variance. For the subsamples, a two-component solution (SZ; 57.0 %) and a three-component solution (C; 65.6 %) fitted best, respectively. For SZ and C, significant associations were found between SFS and external criteria. The main factor “group” emerged as being significant. C showed higher values on both subscales and full scale. The sensitivity of the SFS was examined using discriminant analysis. 86.5% of the participants could be categorized correctly to their actual group. The German translation of the SFS turned out to be a reliable and valid questionnaire comparable to the original English version. This is in line with Spanish and Norwegian translations of the SFS. Concluding, the German version of the SFS is well suited to become a useful and practicable instrument for the assessment of social functioning in both clinical practice and research. It accomplishes commonly used external assessment scales.
    Full-text · Research · Apr 2015 · PLoS ONE
    • "The Social Functioning Scale (SFS) was developed to assess social skills and performance, and to cover functions that are of importance for patients suffering from schizophrenia. Therefore, the SFS reflects the areas focused on in various psychosocial intervention programs [22][23][24]as well as the disabilities and the impairments assessed by the Disability Assessment Schedule [25]. The SFS represents both strengths and weaknesses of the patients in order to facilitate the planning of interventions and individual goals [11]. "
    [Show abstract] [Hide abstract] ABSTRACT: Deficits in social functioning are a core symptom of schizophrenia and an important criterion for evaluating the success of treatment. However, there is little agreement regarding its measurement. A common, often cited instrument for assessing self-reported social functioning is the Social Functioning Scale (SFS). The study aimed to investigate the reliability and validity of the German translation. 101 patients suffering from schizophrenia (SZ) and 101 matched controls (C) (60 male / 41 female, 35.8 years in both groups) completed the German version. In addition, demographic, clinical, and functional data were collected. Internal consistency was investigated calculating Cronbach's alpha for SFS full scale (α: .81) and all subscales (α: .59-.88). Significant bivariate correlation coefficients were found between all subscales as well as between all subscales and full scale (p
    Full-text · Article · Jan 2015
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