Protective Mechanisms of Green Tea Polyphenols in Skin

Department of Dermatology, University Hospitals Case Medical Center, Cleveland, OH 44106-5028, USA.
Oxidative Medicine and Cellular Longevity (Impact Factor: 3.36). 06/2012; 2012(10):560682. DOI: 10.1155/2012/560682
Source: PubMed


Skin is frequently exposed to a variety of environmental, chemical, and genotoxic agents that contribute to disease and carcinogenesis. Ultraviolet light (UVR) is the main external stress that leads to immunosuppression, oxidative stress, premature aging, and tumor formation. Scientists and health professionals emphasize the importance of prevention strategies to circumvent such unfavorable outcomes. Plant polyphenols are a promising approach to disease prevention and treatment. Green tea is an abundant source of plant polyphenols that exhibit significant antioxidant, chemopreventive, and immunomodulatory effects in protecting the skin.

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    • "The main types of cell in the epidermis are keratinocytes that retain its function via a multifarious and tightly controlled program of proliferation and terminal differentiation [2]. Skin is frequently exposed to a variety of environmental, chemical, and genotoxic agents that contribute to disease and carcinogenesis [3]. Exposure of skin to ultraviolet (UV) light is a mutual source of skin damage and is the most important cause of skin cancer [4]. "
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