Case 21-2012: A 27-Year-Old Man with Fatigue, Weakness, Weight Loss, and Decreased Libido

ArticleinNew England Journal of Medicine 367(2):157-69 · July 2012with22 Reads
DOI: 10.1056/NEJMcpc1110053 · Source: PubMed
  • Article · Dec 2012
  • [Show abstract] [Hide abstract] ABSTRACT: The purpose of this article is to clarify the finding of liver function test abnormalities in anorexia nervosa (AN). Literature review and description of two representative cases of severe liver function test abnormalities from our medical stabilization unit. Abnormal elevation of liver function tests can occur during the process of refeeding patients with severe AN. The cause of this elevation is either due to excessive glucose deposition in liver cells or represents liver cell death due to the sequelae of prolonged starvation which characterizes AN before refeeding is adequately in process. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)
    Article · May 2013
  • [Show abstract] [Hide abstract] ABSTRACT: Anorexia nervosa (AN) is a serious disorder that is associated with numerous medical complications and affects both females and males. Severely elevated transaminases have been reported in adult and younger females. We report the first case of elevated transaminases in an adolescent male with AN. The pathophysiologic mechanism of severely elevated serum transaminases observed in malnourished adolescent males with AN is complex and appears to be multifactorial. We present the first case of an adolescent male with AN who developed severely elevated serum transaminases that normalized with improved nutrition and weight gain. Liver injury in patients with AN is a complex medical complication that appears to be multifactorial in origin. In this case, starvation-induced autophagy in the human liver was considered one of the most likely mechanisms to explain hepatocytic injury in this patient. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013).
    Article · Nov 2013
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