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Immunoglobulin levels in manic patients

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  • Sheikh Hasina University of Science and Technology

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The aim of this study was to determine the serum immunoglobulin concentration in both manic patients and in healthy volunteers. The study was conducted with 30 manic patients (24 males and 6 females, aged 55.4 ± 13.0 years); age and gender-matched, control subjects were enrolled. An enzyme-linked immunosorbent assay (ELISA) was employed to analyze the serum immunoglobulin concentrations. IgG level was found to be 18.22±6.42 g/L in the manic patients, while it was 16.05 ± 3.45 g/l in the cohort controls (p=0.487). IgM and IgA concentrations were 6.025 ± 1.07 g/l and 1.41 ± 0.51 g/l in the manic patients, whereas those were 5.73 ± 1.63 g/l (p=0.688) and 0.837 ± 0.36 g/l (p=0.034) respectively in controls. From the results it was found that only the serum concentration of IgA was increased significantly (p=0.034) in manic patients while the concentrations of IgG and IgM remained unchanged. In many psychiatric disorders, immunoglobulin level has been found to be changed significantly. This study reveals that the concentration of IgA in manic patients increased significantly (p=0.034) which usually happens in case of many psychiatric patients. Further studies are suggested with larger population to find out the correlation between immunoglobulin level and degree of disorder and possibility of using as a diagnostic tool for the identification of this disease.
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... A small subgroup of patients, who included six with major depression, one with chronic schizophrenia, and one with a personality disorder, were found to have low IgM concentrations (De-Lisi et al., 1984). An increase of immunoglobulin level was also found in manic patients than the control subjects (Baker et al., 2005). In another study, serum concentration of IgA was significantly decreased in somatization disorder while other IgG and IgM level did not change significantly (Hossain et al., 2007). ...
... These findings are different from other studies in various psychiatric disorders like manic, depression and somatization disorder, where immunoglobulin level decreased significantly compared to the controls (Balaita et al., 1992; Hossain et al., 2007; Marazziti et al., 1992, Mubarak et al., 1999). But the present result is similar with the report of some other investigators who noted a rise of serum concnetartions of IgG, IgA and IgM in schizophrenic and manic patients (Baker et al., 2005; Karim et al., 2005; Tiwari et al., 1989). As somatization and conversion disorder are very similar hence the reason of increase of immunoglobulins in the present study was not clear. ...
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... After clinical intervention, these levels were tends to restore to normal values of control subjects. These findings are similar with previous studies where rises of serum concentrations of IgA and IgM in psychiatric disorders like schizophrenic and manic patients (Baker et al., 2005;Karim et al., 2005;Tiwari et al., 1989). ...
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... Low IgM concentrations were also observed in major depression and chronic schizophrenia when compared with healthy controls [ 26 ] . From the previous study with manic patients, signifi cant increase of the serum concentration of IgA was observed while the concentrations of IgG and IgM remained unchanged [ 27 ] . Signifi cant decrease in serum level of IgA was found in somatization disorder patient when compared with healthy control whereas the change of IgM and IgG was not signifi cant [ 28 ] . ...
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... Low IgM concentrations were also observed in major depression and chronic schizophrenia when compared with healthy controls (Delsi et al., 1984). From the previous study with manic patients, significant increase of the serum concentration of IgA was observed while the concentrations of IgG and IgM remained unchanged (Baker et al., 2005). Interestingly, significant decrease in serum level of IgA was found in somatization disorder patient when compared with healthy control whereas the change of IgM and IgG was not significant (Hossain et al., 2006). ...
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