We construct algebras of pseudodifferential operators on a continuous family groupoid G that are closed under holomorphic functional calculus, contain the algebra of all pseudodifferential operators of order 0 on G as a dense subalgebra, and reflect the smooth structure of the groupoid G, when G is smooth. As an application, we get a better understanding on the structure of inverses of elliptic
... [Show full abstract] pseudodifferential operators on classes of non-compact manifolds. For the construction of these algebras closed under holomorphic functional calculus, we develop three methods: one using two-sided semi-ideals, one using commutators, and one based on Schwartz spaces on the groupoid.