This study develops a specific interactive response system (IRS), called EduClickk, to overcome or alleviate obstacles of classroom interactions. Particularly, several interaction-supporting modes of EduClick are flexibly combined and applied to in-class instruction and learning activities. More than 800 elementary teachers in Taiwan have used EduClick and, in this study, some of the participating teachers were surveyed through questionnaires and interviews. Evaluation results of the application indicate that using EduClick during instruction and learning can increase the utility rate and time of classroom computer, enhance students' motivation and attention, as well as promote teaching quality.