Influence of magnetic iron oxide nanoparticles on red blood cells and Caco-2 cells

Laboratory of Biophysics, Saarland University, 66123, Campus, Saarbruecken, Germany
Advances in Bioscience and Biotechnology 01/2010; 1:439-443.


The interactions of two types of cells (red blood cells, Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca 2+ con-tent. The results show that the nanoparticles do not have a significant influence on the pH and Ca 2+ con-tent of Caco-2 cells. The Ca 2+ content of red blood cells is also not affected but the intracellular pH is slightly reduced.

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