Dyslipidemia in type 2 diabetes mellitus: More atherogenic lipid profile in women

Article (PDF Available)inActa medica Iranica 44(2):111-118 · July 2012with50 Reads
Abstract
Previous studies have shown that diabetes mellitus (DM) increases the risk of cardiovascular disease in women to a greater extent than in men. It seems that DM may alter lipid profiles more adversely in women compared to men. In this study we evaluated serum lipoprotein differences in type 2 diabetic men and women. The study included 350 type 2 diabetic patients (100 men and 250 women), aged 19-82 years. Demographic data were and biochemistry tests including serum lipoproteins were measured. There was no difference between men and women with respect to duration of DM and type of treatment. Body mass index (BMI), systolic and diastolic blood pressures were significantly higher in women than age matched men. Women also had significantly higher plasma levels of total cholesterol (233.7 vs. 190.3 mg/dl, P < 0.001), triglycerides (219.7 vs. 180.6 mg/dl, P < 0.05), low-density lipoprotein cholesterol (LDL-C) (141.2 vs. 116.1 mg/dl, P < 0.001), high-density lipoprotein cholesterol (HDL-C) (47.1 vs. 39.4 mg/dl, P < 0.001), non-HDL cholesterol (186.1 vs. 150.8 mg/dl, P < 0.05), Lp(a) (50.7 vs. 38.2 mg/dl, P < 0.05) and apo-B (117.6 vs. 101.2 mg/dl, P < 0.001). All types of dyslipidemia were significantly more prevalent in females. Women had higher plasma levels of HDL-C compared to men. Higher prevalence of hypertriglyceridemia in females was due to their higher BMI, and sex was not an independent risk factor for hypertriglyceridemia. Type 2 diabetic women are exposed more profoundly to risk factors including atherogenic dyslipidemia and higher BMI, systolic and diastolic blood pressures compared to men.

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    • "The results of present study provide experimental evidence that, there were insignificant differences between mean of cholesterol, TG, LDL-C and HDL-C levels in males when compared with females DM patients with P-value (0.311, 0.281, 0.148, 0.965) respectively, agreed with previous study that found insignificant differences in lipid profile among gender variation [29]. Significant increase in mean cholesterol level was observed in patients who have >5 years type 2 DM in comparison with those have <5 years duration of disease with (P-value 0.035), in contrast the results of others lipids showed insignificant differences among groups classified based on duration of disease, which calcified by previous study, that presence of high prevalence of dyslipidemia (hypercholesterolemia) in type 2 diabetic patients [27]. "
    [Show abstract] [Hide abstract] ABSTRACT: Background: lipid profile had major effect in many diseases worldwide especially atherosclerosis, insulin and vitamin D (vit D) play an important role on the lipids metabolism and its complications. Study aim to evaluate lipid profile level in type 2 diabetes mellitus (DM) with vit D deficiency. Materials and Methods: Descriptive cross sectional study, 120 type2 DM patients aged between 25-80 years old were enrolled, then classified based on vitD results classified into two groups, (<30 ng/ml) considered as cases and (>30 ng/ml) as control groups. VitD, lipid profile (Cholesterol, triglyceride, LDL-C and HDL-C) and glucose were measured in fasting blood samples, using competitive ELISA and Mindray BS-380. Results DM and vitamin D deficient are more common among females. Mean of lipid profile () showed insignificant difference when compared case with control groups, in contrast mean concentration of cholesterol significantly increased in patients who have duration >5 years, in addition no significant differences observed between others lipids and (duration of disease, BMI and gender variations).
    Article · Dec 2014 · Asian Journal of Pharmaceutical and Clinical Research
    • "The results of present study provide experimental evidence that, there were insignificant differences between mean of cholesterol, TG, LDL-C and HDL-C levels in males when compared with females DM patients with P-value (0.311, 0.281, 0.148, 0.965) respectively, agreed with previous study that found insignificant differences in lipid profile among gender variation [29]. Significant increase in mean cholesterol level was observed in patients who have >5 years type 2 DM in comparison with those have <5 years duration of disease with (P-value 0.035), in contrast the results of others lipids showed insignificant differences among groups classified based on duration of disease, which calcified by previous study, that presence of high prevalence of dyslipidemia (hypercholesterolemia) in type 2 diabetic patients [27]. "
    [Show abstract] [Hide abstract] ABSTRACT: Background: lipid profile had major effect in many diseases worldwide especially atherosclerosis, insulin and vitamin D (vit D) play an important role on the lipids metabolism and its complications. Study aim to evaluate lipid profile level in type 2 diabetes mellitus (DM) with vit D deficiency. Materials and Methods: Descriptive cross sectional study, 120 type2 DM patients aged between 25-80 years old were enrolled, then classified based on vitD results classified into two groups, (<30 ng/ml) considered as cases and (>30 ng/ml) as control groups. VitD, lipid profile (Cholesterol, triglyceride, LDL-C and HDL-C) and glucose were measured in fasting blood samples, using competitive ELISA and Mindray BS-380. Results DM and vitamin D deficient are more common among females. Mean of lipid profile () showed insignificant difference when compared case with control groups, in contrast mean concentration of cholesterol significantly increased in patients who have duration >5 years, in addition no significant differences observed between others lipids and (duration of disease, BMI and gender variations).
    Full-text · Article · Dec 2014 · Asian Journal of Pharmaceutical and Clinical Research
    • "T2DM is regarded as a long-term disease without variable clinical manifestation and progression of diseases. Chronic hyperglycemia can cause dyslipidemia, hypothyroidism and elevated thyroid stimulating hormone, CVD, renal diseases, neurological problems and recurrent infections [10]. T2DM is associated with a cluster of interrelated plasma lipid and lipoprotein (Lp) abnormalities that are all recognized as predictors for CHD. "
    [Show abstract] [Hide abstract] ABSTRACT: Objectives: More cardiovascular disease occurs in patients with either Type 1 diabetes mellitus (DM) or Type 2 DM (T2DM). Serum high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol profiles in T2DM is quite useful, as it may serve as a reliable monitor to judge the prognosis of the patients. The aim of the present study is to examine T2DM and dyslipidemia and their correlation in residents of Nepal. The detection of risk factors in the early stage of the disease will help the patients to improve and reduce the morbidity rate as LDL promotes cholesterol deposition in the arterial wall. Methods: This case-control study was carried out in Lumbini Medical College, Palpa, Nepal, on total of 100 subjects, with 50 controls (non-diabetic cases) and 50 T2DM patients, to study their HDL and LDL profiles. Results: The present study showed increased levels of fasting blood sugar (164.5 [51.17] than in control 95.4 [10.09]) and LDL cholesterol (121.4 [27.89] than in control 103.6 [30.67]) in T2DM subjects; conversely, serum HDL cholesterol (39.2 [7.96]) level was reduced significantly in T2DM patients (than in controls 44.0 [10.57]). Conclusion: Thus, the findings of the present study imply a significant correlation between serum HDL and LDL cholesterols in T2DM subjects.
    Full-text · Article · Nov 2014
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