Validation of the Face Name Associative Memory Exam in cognitively normal older individuals

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Journal of Clinical and Experimental Neuropsychology (Impact Factor: 2.08). 07/2012; 34(6):580-7. DOI: 10.1080/13803395.2012.666230
Source: PubMed


The recently developed Face Name Associative Memory Exam (FNAME), a challenging paired associative learning task, shows promise in detecting the subtle cognitive changes characteristic of preclinical Alzheimer's disease. In this study, we evaluated the validity and reliability of the FNAME in 210 cognitively normal older individuals (58-90 years of age). Construct validity of the measure was assessed by principal components analysis, which revealed two independent factors. Correlations between the FNAME subtests and another episodic memory test were significant. The results indicated strong test-retest reliability in a subsample (n = 41). Normative data stratified by age were also generated.

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Available from: Dorene Rentz, Dec 16, 2013
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    • "S-FNAME total scores were not related to either anxiety/depression HAD scores or to SMI on the MFE-30. These findings are consistent with the results obtained in our previous study about the validation of the S-FNAME in CN older individuals [44] and to the original FNAME validation in which FNAME scores were highly correlated with another recognized test of episodic memory, the 6-Trial Selective Reminding Test [23]. It is consistent with previous studies demonstrating that S-FNAME is a complex test sensitive to episodic memory. "
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    ABSTRACT: Background: Subjective memory impairment (SMI) refers to subjective awareness of initial memory decline undetectable with existing standardized cognitive tests. The Face Name Associative Memory Exam (FNAME) was created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). We reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively normal (CN) Spanish-speaking subjects >49. Objective: To determine whether higher SMI [a modification of Memory Failures Everyday (MFE-30)] was related to worse memory performance (S-FNAME) or associated with greater affective symptoms in subjects >49; and whether MFE-30 and FNAME were able to discriminate between CN and mild cognitive impairment (MCI) subjects. Methods: 317 subjects (CN = 196, MCI = 121) were included in the analysis because they attended the annual "Open House Initiative" at Memory Clinic Fundació ACE, were >49 years, literate, received S-FNAME, MFE-30, and Hospital Anxiety and Depression Scale, had Mini-Mental State Exam scores ≥27, and returned to complete a comprehensive diagnostic assessment. Results: MFE-30 scores were associated with affective symptoms but not with S-FNAME performance. S-FNAME scores were related to performance on memory variables of NBACE (neuropsychological battery used in Fundació ACE). Although the MCI group showed significantly higher MFE-30 and worse S-FNAME scores than the CN group, their discriminability values were similar (Sensitivity: 49.6 versus 52.9; Specificity: 85.1 versus 83.6, respectively). Conclusions: SMI was more related to depressive symptoms than to S-FNAME memory performance; and S-FNAME scores were related to other episodic memory test performances, but neither to affective symptoms nor to SMI. MFE-30 and S-FNAME are not optimal for discriminating between CN and MCI groups. Longitudinal follow-up will determine if lower S-FNAME and higher SMI are related to increased risk of AD.
    Full-text · Article · Oct 2015 · Journal of Alzheimer's disease: JAD
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    • "l in the SRT . We estimated the effects of age , education , and gender on S - FNAME performance . Age and gender had a statistically signifi - cant effect on the S - FNAME , but not on education . Again , these findings are consistent with previous studies demonstrating that verbal learning and memory is affected by age ( Alegret et al . , 2012 ; Amariglio et al . , 2012 ; Gómez - Pérez & Ostrosky - Solís , 2006 ; Lezak , Howieson , & Loring , 2004 ; Manubens et al . , 2005 ; Norman , Evans , Miller , & Heaton , 2000 ; Peña - Casanova et al . , 2009 ; Wechsler , 1997 ) and gender ( Alegret et al . , 2012 ; Lezak et al . , 2004 ; Norman et al . , 2000 ) . The best S - FNAME scores were obtained by women "
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    ABSTRACT: The Face Name Associative Memory Exam (FNAME) is a paired associative memory test that has demonstrated sensitivity to amyloid burden in cognitively normal individuals, a biomarker of preclinical Alzheimer's disease. Normative data adjusted for age were reported in American healthy individuals older than 57. We aimed to report the psychometric characteristics of a Spanish version of FNAME (S-FNAME) when administered to Spanish-speaking people. We sought to investigate convergent validity of S-FNAME with another memory measure and to identify which demographic characteristics might be associated with performance on S-FNAME. We administered the S-FNAME to 110 literate, cognitively normal, Spanish individuals older than 49 years from the Memory Clinic Fundació ACE. Construct validity of S-FNAME showed 2 components: face-name and face-occupation. A significant correlation between S-FNAME and Word List from the WMS-III supported convergent validity. The S-FNAME was also associated with age and gender. Thus, we provide normative data for age and gender. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail:
    Full-text · Article · Aug 2015 · Archives of Clinical Neuropsychology
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    • "Using the factor weights from this prior analysis, a factor score for memory was derived for each participant. The tests included in this factor score are the following: number of errors produced on the Self-Ordered Pointing task (95% of older participants completed; adapted from Petrides and Milner, 1982; Shimamura and Jurica, 1994), cued recall names, and cued recall occupations scores from the Face-Name Associative Memory Exam (99% of older participants completed; Amariglio et al., 2012; Rentz et al., 2011), delayed recall from the Six- Trial Selective Reminding Test (99% of older participants completed; Masur et al.,1990), and Free Recall, list two, from the Memory Capacity Test (99% of older participants completed; Rentz et al., 2010). Missing data on individual tests were imputed using a linear regression approach. "
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    ABSTRACT: Advanced aging negatively impacts memory performance. Brain aging has been associated with shrinkage in medial temporal lobe structures essential for memory-including hippocampus and entorhinal cortex-and with deficits in default-mode network connectivity. Yet, whether and how these imaging markers are relevant to age-related memory deficits remains a topic of debate. Using a sample of 182 older (age 74.6 ± 6.2 years) and 66 young (age 22.2 ± 3.6 years) participants, this study examined relationships among memory performance, hippocampus volume, entorhinal cortex thickness, and default-mode network connectivity across aging. All imaging markers and memory were significantly different between young and older groups. Each imaging marker significantly mediated the relationship between age and memory performance and collectively accounted for most of the variance in age-related memory performance. Within older participants, default-mode connectivity and hippocampus volume were independently associated with memory. Structural equation modeling of cross-sectional data within older participants suggest that entorhinal thinning may occur before reduced default-mode connectivity and hippocampal volume loss, which in turn lead to deficits in memory performance.
    Full-text · Article · Jul 2014 · Neurobiology of Aging
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