Unusual initial development of an esthesioneuroblastoma above the cribriform plate

Department of Radiology, Clinique St-Pierre, Ottignies, Belgium.
JBR-BTR: organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) 03/2012; 95(2):89-91. DOI: 10.5334/jbr-btr.146
Source: PubMed


Esthesioneuroblastoma is a rare tumor localized in the superior part of the nasal cavity. Extension in the anterior cerebral fossa is sometimes observed. As we discovered in our patient, the location of the tumor above the cribriform plate was very unusual and meningioma was suspected. Features and prognosis are discussed below.

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    ABSTRACT: Olfactory neuroblastoma (ONB) is a rare tumour of nasal cavity and paranasal sinuses that arises from the olfactory neuroepithelium and has unpredictable clinical course. As the sense of smell is phylogenetically one of the first senses and olfactory neuroepithelium is evolutionary conserved with striking similarities among different species, we performed an extensive analysis of the literature in order to evaluate the similarities and differences between animals and humans on the clinical, morphological, immunohistochemical, ultrastructural and molecular level. Our analysis revealed that ONB was reported mainly in mammals and showed striking similarities to human ONB. These observations provide rationale for introduction of therapy modalities used in humans into the veterinary medicine. Animal models of neuroblastoma should be considered for the preclinical studies evaluating novel therapies for ONB.
    Full-text · Article · Jul 2014 · Veterinary and Comparative Oncology