Identification of a novel HLA allele, HLA-DQB1*06:51, in a Japanese rheumatoid arthritis patient
Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Kanagawa, 252-0392, Japan. Tissue Antigens
(Impact Factor: 2.14).
07/2012; 80(4):386-7. DOI: 10.1111/j.1399-0039.2012.01921.x
A novel HLA allele, HLA-DQB1*06:51, was identified in a Japanese rheumatoid arthritis patient.
Available from: Kiyoshi Migita
- "One of each DRB1 and DQB1 locus could not be typed in the present study. These were revealed to be novel HLA alleles, DRB1* 08∶36∶02 and DQB1*06∶51, by sequencing of the isolated alleles . "
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ABSTRACT: Autoantibodies to ribonucleoprotein are associated with a variety of autoimmune diseases, including rheumatoid arthritis (RA). Many studies on associations between human leukocyte antigen (HLA) alleles and RA have been reported, but few have been validated in RA subpopulations with anti-La/SS-B or anti-Ro/SS-A antibodies. Here, we investigated associations of HLA class II alleles with the presence of anti-Ro/SS-A or anti-La/SS-B antibodies in RA.
An association study was conducted for HLA-DRB1, DQB1, and DPB1 in Japanese RA and systemic lupus erythematosus (SLE) patients that were positive or negative for anti-Ro/SS-A and/or anti-La/SS-B antibodies.
An increased prevalence of certain class II alleles was associated with the presence of anti-Ro/SS-A antibodies as follows: DRB1*08∶03 (Pc = 3.79×10(-5), odds ratio [OR] 3.06, 95% confidence interval [CI] 1.98-4.73), DQB1*06∶01 (Pc = 0.0106, OR 1.70, 95%CI 1.26-2.31), and DPB1*05∶01 (Pc = 0.0040, OR 1.55, 95%CI 1.23-1.96). On the other hand, DRB1*15∶01 (Pc = 0.0470, OR 3.14, 95%CI 1.63-6.05), DQB1*06∶02 (Pc = 0.0252, OR 3.14, 95%CI 1.63-6.05), and DPB1*05∶01 (Pc = 0.0069, OR 2.27, 95% CI 1.44-3.57) were associated with anti-La/SS-B antibodies. The DPB1*05∶01 allele was associated with anti-Ro/SS-A (Pc = 0.0408, OR 1.69, 95% CI 1.19-2.41) and anti-La/SS-B antibodies (Pc = 2.48×10(-5), OR 3.31, 95%CI 2.02-5.43) in SLE patients.
HLA-DPB1*05∶01 was the only allele associated with the presence of both anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese RA and SLE patients.
Available from: Steven G E Marsh
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