Biological mechanisms of normal tissue damage: Importance for the design of NTCP models

ArticleinRadiotherapy and Oncology 105(1) · June 2012with42 Reads
Impact Factor: 4.36 · DOI: 10.1016/j.radonc.2012.05.008 · Source: PubMed


    The normal tissue complication probability (NTCP) models that are currently being proposed for estimation of risk of harm following radiotherapy are mainly based on simplified empirical models, consisting of dose distribution parameters, possibly combined with clinical or other treatment-related factors. These are fitted to data from retrospective or prospective clinical studies. Although these models sometimes provide useful guidance for clinical practice, their predictive power on individuals seems to be limited.