Targeting hematoma expansion in ICH Illusions of hope or hope to disillusion
Correspondence & reprint requests to Dr. Selim: .Neurology (Impact Factor: 8.29). 06/2012; 79(4):298-9. DOI: 10.1212/WNL.0b013e318260cda7
Several variables are associated with poor outcome and mortality after intracerebral hemorrhage (ICH).(1) Among modifiable factors, hematoma expansion may have a predominant role, and has been the target of recent therapeutic trials in ICH. The Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) and Antihypertensive Treatment of Acute Cerebral Hemorrhage Study (ATACH-1) showed that intensive blood pressure (BP) lowering is associated with reduced hematoma expansion during the first 24 hours of ICH(2,3); the clinical effectiveness of this strategy is undergoing evaluation in phase III trials.
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