Complete Genome Sequence of an H7N3 Avian Influenza Virus Isolated from Ducks in Southern China

MOA Key Laboratory for Animal Vaccine Development, Key Laboratory of Zoonoses Control and Prevention of Guangdong, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Journal of Virology (Impact Factor: 4.44). 07/2012; 86(14):7724-5. DOI: 10.1128/JVI.01063-12
Source: PubMed


We report here the complete genomic sequence of an H7N3 avian influenza virus (AIV) isolate, which was obtained from duck
in 1996. This is the first report of this subtype of AIV being isolated from duck in Guangdong of Southern China. Genomic
sequence and phylogenetic analyses showed that it was highly homologous with the wild bird virus A/ruddy turnstone/Delaware
Bay/135/1996 (H7N3) and that all eight genes of this virus belonged to the North America gene pool. The availability of genome
sequences is helpful to further investigations of epidemiology and evolution of AIV between waterfowl and wild birds.

Download full-text


Available from: Peirong Jiao, May 10, 2014
  • Source
    • "However, only one strain, H9N2 virus, was isolated from humans in Hong Kong in 2008 and there have been no H7 subtype AIVs isolated in Hong Kong in recent years. In Southern China, H5N1 AIV was isolated from a condor in Guangdong in 200324; H5N2 and H5N1 AIV were isolated from parrots in Guangdong in 2004 and 20052526, respectively; several H9N2 AIVs were isolated from water and fowl feces in the Dongting Lake wetland in 200727, and from broilers in Fujian in 200928; 4 H7N3AIVs were isolated from domestic ducks in Zhejiang in 201129; H6N2 AIV was isolated from a chicken in Guangdong in 201130; recombinant H9N2 AIV from fresh egret feces in the wetland in 201231; and H10N8 AIVs were isolated from water samples of the wetland in 201132, and from a duck in Guangdong in 201233. Prior reports showed that from January 2000 through April 2001, multiple H3N6, H9N2, H2N9, H3N3, and H4N6 AIVs and single H1N1 and H3N2 AIVs were isolated from a Nanchang live poultry market34. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Extensive surveillance of influenza A viruses in different avian species is critical for understanding its transmission. Here, a breeding colony of Little Egrets and Black-crowned Night Herons was monitored both serologically and virologically in a city park of Jiangxi in 2009. A portion of herons had antibodies against H7 (52%), H5 (55%) and H9 (6%) subtype avian influenza virus (AIV) in egg yolk samples, and 45% had antibodies against different AIV serotypes (H5, H7 or H9) simultaneously. Greater numbers of samples with anti-AIV H5N1 recombination-4 (Re-4, clade 7) antibodies were measured compared with those containing anti-H5N1 Re-1 (clade 0) and Re-5 (clade 2.3.4) antibodies. Eight strains of H5 and 9 strains of H9 were isolated from poultry of nearby markets. These results indicate wild birds are at risk from infection and co-infection with H7, H5, and H9 subtypes. Investigation of wild bird infection might provide an early warning sign of potential novel AIVs circulating in the nearby poultry industry and even in human society.
    Full-text · Article · Sep 2014 · Scientific Reports
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Zoonotic transmission of pathogenic avian influenza virus is a potential public health threat (1, 2), as the virus may acquire human to human transmissibility through mutations or by reassortment with seasonal influenza viruses (H3N2 and H1N1).…
    Preview · Article · Sep 2013 · Journal of clinical microbiology
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Following the first human infection with the influenza A (H10N8) virus in Nanchang, China in December 2013, we identified two additional patients on January 19 and February 9, 2014. The epidemiologic, clinical, and virological data from the patients and the environmental specimen collected from 23 local live poultry markets (LPMs) were analyzed. The three H10N8 cases had a history of poultry exposure and presented with high fever (>38°C), rapidly progressive pneumonia and lymphopenia. Substantial high levels of cytokines and chemokines were observed. The sequences from an isolate (A/Environment/Jiangxi/03489/2013 [H10N8]) in an epidemiologically linked LPM showed highly identity with human H10N8 virus, evidencing LPM as the source of human infection. The HA and NA of human and environmental H10N8 isolates showed high identity (99.1-99.9%) while six genotypes with internal genes derived from H9N2, H7N3 and H7N9 subtype viruses were detected in environmental H10N8 isolates. The genotype of the virus causing human infection, Jiangxi/346, possessed a whole internal gene set of the A/Environment/Jiangxi/10618/2014(H9N2)-like virus. Thus, our findings support the notion that LPMs can act as both a gene pool for the generation of novel reassortants and a source for human infection, and intensive surveillance and management should therefore be conducted.
    Full-text · Article · Jan 2015 · Scientific Reports
Show more