The world within: Living with our microbial guests and guides

Mucosal and Vaccine Research Colorado, Division of Infectious Diseases, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colo
Translational research : the journal of laboratory and clinical medicine 06/2012; 160(4):239-45. DOI: 10.1016/j.trsl.2012.05.005
Source: PubMed


Initially considered benign, commensal microbes are now recognized as primarily beneficial to the host, significantly affecting human health and disease. Indeed, changes in the normal intestinal bacteria have been clinically correlated with susceptibility to infections, intestinal inflammation, allergies, and autoimmune disease. We consider the known relationships between emerging characterizations of the human microbiome with clinical syndromes in the context of 4 thoughtful reviews of the microbiome in the human intestinal tract, the lung, and the vagina, as well as a more recent discipline, the human virome. The challenges are to move beyond description and correlation to devise creative and predictive study designs and models to establish causal relationships among the microbiome, metagenome, and clinical syndromes.

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Available from: Claire E Gustafson, Feb 05, 2015
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