Neuroprotection of the optic nerve in glaucoma

Yale University School of Medicine, New Haven, Conn., USA
Acta Ophthalmologica Scandinavica (Impact Factor: 1.85). 05/2009; 75(4):364 - 367. DOI: 10.1111/j.1600-0420.1997.tb00391.x
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    • "Glaucoma: causes and treatments The treatment of glaucoma to date has been based largely on eliminating one type of trauma to the cells, specifically, intraocular pressure higher than the neurons can tolerate. Where the effect of lowering intraocular pressure does not prevent continuing damage, or where the intraocular pressure cannot be lowered adequately, it would make sense to intervene in a different way to prevent the trauma from starting the cascade of apoptotic events; trying to halt the cascade once it has been initiated could also help (Caprioli 1997; Schwartz et al. 1996). For example, if, following initiation of apoptosis due to elevated intraocular pressure, the basic problem was interference with axoplasmic transport and deprivation of a neurotrophic factor, perhaps the neurotrophic factor could be supplied directly, halting the apoptotic process. "

    Full-text · Article · Feb 1998 · Acta ophthalmologica Scandinavica. Supplement

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