The lymphoid system. Its normal architecture and the potential for its understanding by the study of lymphoproliferative diseases

ArticleinHuman Pathlogy 9(1):25-45 · February 1978with6 Reads
Impact Factor: 2.77 · DOI: 10.1016/S0046-8177(78)80005-7 · Source: PubMed


    This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic lymphocytes in humans is defined and compared with animal model systems.