Antioxidant and Anticholinesterase Constituents from the Petroleum Ether and Chloroform Extracts of Iris suaveolens
The aim of this study was to investigate the phytochemical, antioxidant and anticholinesterase activities of Iris suaveolens. After determining total phenolic and flavonoid contents of the petroleum ether, chloroform and methanol extracts prepared from the rhizomes, the antioxidant capacity of the extracts was established using β-carotene–linoleic acid and CUPRAC methods. The chloroform extract which was rich in phenolic content exhibited the highest inhibition of lipid peroxidation in the β-carotene–linoleic acid system, and the best cupric reducing antioxidant capacity among the tested extracts. The petroleum ether extract indicated moderate anticholinesterase activity while the chloroform extract revealed significant butyrylcholinesterase inhibitory activity (75.03 ± 1.29%). Spectroscopic methods were used for the structural elucidation of the compounds (1–13) isolated from the petroleum ether and chloroform extracts. Coniferaldehyde (6), having the highest antioxidant activity in the β-carotene–linoleic acid assay at 25 and 50 µg/mL, demonstrated also the best effect in the CUPRAC method among the tested compounds (1–12). 3-Hydroxyirisquinone (10) showed the best anticholinesterase activity among the tested compounds (1–4, 6–12), and coniferaldehyde exhibited almost the same butyrylcholinesterase inhibitory activity (82.60 ± 2.33%) as galantamine (86.26 ± 0.66%). Copyright © 2010 John Wiley & Sons, Ltd.
Available from: Wirginia Kukula-Koch
- "MPLC separation carried out using a stepwise gradient of MeOH:H 2 O and preparative HPLC were applied for separation of 9, 28, 41, and 42 from the chloroform extract. For 26, 44, and soforanarin A, the final purification was achieved on preparative TLC plates (Hacibekiroglu and Kolak 2011). "
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ABSTRACT: Roots and rhizomes of many Iris species are well known as precious sources of isoflavones.
They have been used in traditional medicine to treat respiratory disorders and decrease smooth muscles activity. Recent advances in their phytochemistry and phytomedicine have revealed potent anticholinesterase, antineoplastic and anti-plasmodial activities of iris constituents. Furthermore, decoctions from rhizomes have been successfully used among patients with hormone-related diseases. Except for isoflavones, the main chemical components of Iris are xanthones, quinones, flavons, terpenes and simple phenolics, with
multiple biological activities. This contribution reviews the research progress of the past 30 years relating to the chemistry, recovery of secondary metabolites, their separation by means of TLC and HPLC techniques and spectral data of the most common chemical components of iris extracts. Special attention is paid to ultraviolet spectroscopy, infrared spectroscopy, LC–mass spectroscopy and nuclear magnetic resonance analyses of isoflavones, flavons,
xanthones and terpenes.
Available from: ijbbb.org
- "Recently many medicinal plants have been screened to know for their anti-cholinesterse property . The extracts prepared from cinnamon [Cinnamomum cassia Presl (Lauraceae) , Iris suaveolens , Ficus carica , Tutin, (Umbelliferae),  and Datura stramonium  have shown anticholoinestrase potential. Alzheimer's "
Available from: Işıl Gazioğlu
- "A literature survey showed that the anti - cholinesterase activity of only two Iris species , Iris pseudopumi - la and Iris suaveolens , had been investigated ( Conforti et al . , 2009 ; Hacıbekirog˘ lu and Kolak , 2011 ) . Flavonoids , especially isoflavones , and their glycosides , are the main constituents of Iris species ( Al - Khalil et al . "
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