The study of the clinical psychological profile of the cancer patients has received increasing attention and interest in the scientific community, however, more often under the light of quantitative rather than qualitative research studies, while vast opportunities for using qualitative methods exist within cancer patients research as far as the palliative care concept is concerned. Generally, it could be stated that qualitative methods, although presented in a few studies, can be served as a versatile set of tools and a necessary complement to quantitative analysis in the field of palliative care, especially for the patients of this diagnostic category. This study shows, inter alia, how qualitative research is uniquely positioned to contribute to ongoing clinical trial development and analysis and provides a demystifying introduction to qualitative methods for interested palliative care clinicians, clinical psychologists, and investigators. The purpose of the present study is to highlight the psychological profile of the group of the cancer patients throughout certain qualitative “filters”, that is to say applying a semi-structured clinical interview, designed especially for the needs of the present study, as well as throughout the use of a theoretical conceptual framework based on the axioms of analysis of the Grounded Theory. Semistructured clinical interview aimed not only to describe phenomena, rather than report statistics, but also to understand the views and feelings of patients in palliative care settings (early palliative care) towards the “bad news” and explore their opinions regarding the timing of its discussion as well, and, consequently, each analyzed item provides a wealth of data, for example the emotional labor, the prolonged agony, the desires of the patient, and, finally, the silent acting-out. Additionally, throughout the subjects’ narrative interventions, for the first time in this research field (palliative care), three (3) “cognitive entrapments”, linked to the onset of the disease, were found and emerged, simultaneously. The final completion of the outline of the participants' psychological profile it has been made possible by using the Thematic Apperception Test (Τ.Α.Τ), as it was not only more appropriate than the first psychological tool so as to bring out more internal, more insidious, more obscure and more entrenched emotional and mental processes, but also more suitable for the assessment of the diversity of the defense functions and their levels as well. The findings of both psychological tools were analyzed on the basis of the methodological principles and axioms of the Grounded Theory and on purely psychodynamic terminology. Finally, a reference is made to the use of these findings of the study, both on the clinical practice with oncological patients and on the education of the health professionals. Last but not least, reference is made to the research constraints that are fatally "accompanying" each study.