Objective. Little is known about the impact of loneliness on physical health among elderly individuals with diabetes. Here, we examined the relationship of loneliness with disability, objective physical function, and other health outcomes in older individuals with type 2 diabetes and overweight or obesity. Method. Data are drawn from the Look AHEAD study, a diverse cohort of individuals (ages 61–92) with overweight or obesity and type 2 diabetes measured 5–6 years after a 10-year weight loss randomized, controlled trial. Results. Loneliness scores were significantly associated with greater disability symptoms and slower 4-meter gait speed (). Loneliness did not differ across treatment arms. Discussion. Overall, these results extend prior findings relating loneliness to disability and decreased mobility to older individuals with type 2 diabetes and overweight or obesity.
1. Introduction
Loneliness is a subjective state, reflecting a lack of desired closeness with friends, family, and loved ones. Compared with structural measures of social contacts, counting an individual’s opportunities for interaction with other people, loneliness assesses the function of social interactions in allowing a person to feel connected to others [1]. Living alone, widowhood, poor health status, and poor functional status each increase risk for loneliness [2, 3]. Roughly, 25–43% of adults over the age of 70 report being lonely [4].
Loneliness is a well-established correlate of mental health, quality of life [5–7], and early mortality in older adults [8–14]. Moreover, loneliness has previously been shown to relate to disability [15, 16] and impaired mobility [17]. For example, loneliness predicted a faster rate of objectively-measured motor decline, defined by motor function and muscle strength, over five years of follow-up among 985 men and women, with a mean age of 80 [17]. Perissinotto and colleagues [13] found that loneliness was related to greater difficulty with activities of daily living and mobility at six year follow-up among over 14,000 men and women over the age of 60 in the Health and Retirement Study. Higher levels of loneliness also predicted frailty as defined by the Fried Formula at 4 year follow-up among 2,817 individuals over 60 years of age from the English Longitudinal Study of Aging [15]. Interestingly, Hoogendijk and colleagues [18] reported that frailty increased the risk for loneliness over 3 years, suggesting that the relationship between loneliness and physical function may be bidirectional [18].
Little is known about how loneliness relates to health status among older individuals with type 2 diabetes. In the United States, 25% of individuals over the age of 65 have type 2 diabetes [19] increasing the risk for early mortality, cardiovascular disease, renal disease, dementia, functional impairment, depression, and vision impairment [20]. Although less stringent treatment goals can be recommended for elderly individuals, the need for diabetes self-management remains including treatment adherence, nutrition, and exercise [21]. Social support improves diabetes self-management, medication adherence, diet change, active lifestyles and, in some cases, glycemic control [22]. Conversely, loneliness is associated with less physical activity [23, 24] and poorer sleep quality [25, 26]. As such, it is plausible that loneliness may relate to health outcomes among elderly individuals with type 2 diabetes but these associations have not been established.
Look AHEAD was a randomized controlled trial designed to determine whether 10 years of intensive lifestyle intervention (ILI), comprised of calorie restriction and physical activity promotion to achieve weight loss, improves health outcomes among older individuals with type 2 diabetes and overweight or obesity, relative to a Diabetes Support and Education (DSE) control group. The cohort was reassessed for aging-related outcomes at 15-year follow-up, including loneliness measured for the first time. The goal of this paper is to characterize the prevalence of loneliness among individuals with type 2 diabetes and overweight or obesity in the Look AHEAD cohort and to determine cross-sectional associations of loneliness score with self-reported disability and objective mobility and other health indicators, including HbA1c, quality of life, and depressive symptoms. It is hypothesized that loneliness will relate to (1) greater disability and decreased mobility and physical function, as defined by the 400 m walk, grip strength, and the Short Physical Performance Battery and (2) higher HbA1c and depressive symptoms and lower quality of life.
2. Methods
2.1. Research Design
Look AHEAD is a randomized, controlled trial designed to test whether 10 years of ILI, combining calorie restriction and physical activity to produce weight loss, improves health outcomes among individuals with type 2 diabetes and overweight or obesity, relative to DSE [27, 28] (see Supplementary File 2). The cohort was reassessed at year 15 to continue to follow diabetes and aging-related outcomes, including measuring loneliness for the first time. The study enrolled 5,145 men and women, aged 45–76 at baseline. The present study is cross-sectional and derives variables from 15 year follow-up when participants had a mean age of 75 (range: 61–92). All Look AHEAD participants who were attending clinical visits were included (n = 3187). Look AHEAD participants who were followed only through telephone interviews (n = 300) were excluded because loneliness was not queried.
2.2. Study Interventions
Eligible patients were randomly assigned to participate in ILI (intervention group) or DSE (comparison group), with stratification according to clinical site. Curricula for the two study groups were developed centrally and have been described in detail previously [27, 28].
2.3. Intensive Lifestyle Intervention (ILI)
The ILI included calorie restriction, low-fat diet, and increased physical activity and was designed to induce at least a 7% weight loss at year 1 and to maintain this weight loss in subsequent years. ILI participants were assigned a calorie goal (1200–1800 kcal/d based on initial weight), with less than 30% of total calories from fat (<10% from saturated fat) and a minimum of 15% of total calories from protein. The exercise goal was at least 175 minutes of physical activity per week, using activities similar in intensity to brisk walking. ILI participants were seen for 3 groups and one individual session per month for the first 6 months and 2 group, one individual session per month for the next 6 months, and at least monthly through year 10. ILI was effective in inducing and sustaining weight losses relative to the control condition throughout follow-up [28].
2.4. Diabetes Support and Education (DSE)
DSE featured three group sessions per year focused on diet, exercise, and social support during years 1 through 4. In subsequent years, the frequency was reduced to one session annually.
3. Measures
3.1. Loneliness
Loneliness was measured using the UCLA Brief Loneliness Scale [29]. The scale contains three questions: “How often do you feel that you lack companionship?”, “How often do you feel left out?”, and “How often do you feel isolated from others?” Each item has the response choices of “Hardly ever,” “Some of the time,” and “Often,” assigned scores 0, 1, and 2 respectively. These scores for each of the items are summed to give a total score. The prevalence of loneliness has also been defined as reporting “Some of the time” or “Often” relative to “Hardly ever” for at least one of the three questions: “How often do you feel that you lack companionship?”, “How often do you feel left out?” and “How often do you feel isolated from others?” [13]. The UCLA Brief Loneliness Scale was shown to have a strong correlation with the full UCLA Loneliness Scale (r = 0.82) and to have reasonable internal consistency (Cronbach’s α = 0.72) [29].
3.2. Disability and Physical Function
3.2.1. Pepper Assessment Tool for Disability (PAT-D)
The PAT-D is an 18-item self-report questionnaire designed to assess disability in older adults. Participants are asked to rate: “How much difficulty, if any, do you have with each of these activities? Think about the past month. How hard was it to do the activity because of your health?” Items include questions such as “Moving in and out of bed” and “Dressing yourself.” Responses range from “Usually did with no difficulty” (1) to “Unable to do” (5) with the possibility of endorsing “Usually did not do for other reasons.” Scores are averaged across the 18 items. The PAT-D has shown strong internal consistency (α = 0.82) and test-retest reliability (r > 0.70).
3.2.2. Physical Function Tests
Objective physical function was assessed in the full cohort at an average of 15–16 year follow-up. The Short Physical Performance Battery Expanded (SPPBexp) [30], a modestly expanded form of the Short Physical Performance Battery [31] designed to minimize ceiling effects of the SPPB when used in well-functioning populations, was administered to assess lower extremity physical function. The SPPB consists of standing balance tasks (side-by-side, semi- and full-tandem stands for 10 seconds each), a 4 m walk to assess usual gait speed and time to complete five repeated chair stands. The SPPBexp increased the holding time of the standing balance tasks to 30 seconds and added a single leg stand. The SPPBexp component scores are calculated as the ratio of observed performance to the best possible performance and summed to provide a continuous score ranging from 0 to 3, with higher scores indicative of better performance. Usual walking speed over 20 m and walking endurance over 400 m were measured [32]. The course was 20 m long and marked by cones at each end. Participants were instructed to walk at their usual pace, and time to complete the first 20 m and the longer 400 m was recorded. Grip strength (kg) was measured twice in each hand using an isometric Hydraulic Hand Dynamometer (Jamar, Bolingbrook, IL). The maximum force from two trials for the stronger hand was used in the analyses.
3.3. Other Health Indicators
3.3.1. Personal Health Questionnaire-9 (PHQ-9)
The PHQ-9 is a self-administered questionnaire assessing depressed mood and depression severity [33]. The questionnaire asks “How often, over the past two weeks, have you been bothered by any of the following problems?” for nine questions, including “Little interest or pleasure in doing things” and “Feeling down, depressed, or hopeless.” Response options include “Not at all,” “Several days,” “More than half of the days,” and “Nearly every day.” Depressed mood severity was calculated by assigning response options scores of 0–3 based on increasing frequency and summing the scores (range: 0–27). The PHQ-9 has strong internal consistency (α = 0.89) and test-retest reliability (r = 0.84) in clinical samples [33]. The PHQ-9 does not include a loneliness item.
3.3.2. Antidepressant Medications
Participants brought all prescription medications to their annual clinic assessment visits, and these medications (but not the dosages) were recorded by study staff. Antidepressant medications were identified using the Food and Drug Administration classification system.
3.3.3. Quality of Life
Quality of life was assessed using the SF-36 General Health questionnaire [34]. The questionnaire asks participants: “In general, would you say your health is…” with responses ranging from Excellent (1) to Poor (5) on a 1–5 scale. Lower values indicate better general health.
3.3.4. HbA1c and Diabetes Medications
HbA1c was assayed from fasting blood samples. Six major classes of diabetes medications were categorized from the Food and Drug Administration classification system and were used as covariates in analyses of HbA1c.
3.4. Statistical Analysis
Primary analyses were conducted using linear or logistic regression depending on the outcome. Model 1 tested the association of loneliness, age, sex, race, and ethnicity with the function- and health-related variables. Model 2 added depressive symptoms and antidepressant medications to determine whether loneliness relates to the other variables independent of correlated constructs also known to relate to health outcomes. For the relationship of loneliness to HbA1c, the six major categories of diabetes medications were added as covariates to Model 2. Treatment arm was added in Model 3 to determine whether loneliness differs by ILI.
PHQ-9 and PAT-D scales are extremely skewed, even after log transformation, and thus were dichotomized at their lowest value vs anything else.
4. Results
4.1. Descriptive Statistics
Descriptive statistics for baseline and the Look AHEAD E visit (15-year follow-up) are presented in Table 1. The balance afforded by the original randomization was maintained at the 15-year visit: no differences in baseline age, sex, race, or Hispanic ethnicity were observed. However, several health indices continued to show intervention effects, including lower BMI (32.9 vs 33.6; ), faster gait speed (4.85 vs 5.00 seconds; ), and less insulin use (43.4% vs 49.5%; ) in the ILI compared with DSE groups. No differences in loneliness by Look AHEAD treatment arm were observed ().
Nonmissing
Overall
Intervention arm
value
DSE
ILI
N
3190
1553
1634
Baseline characteristics
Age
3190
58.3 (6.4)
58.3 (6.4)
58.2 (6.3)
0.7042
BMI
3190
35.9 (6.0)
36.0 (5.8)
35.7 (6.1)
0.1338
Gender
3190
0.4756
Male
1214 (38.1%)
581 (37.4%)
633 (38.7%)
Female
1976 (61.9%)
973 (62.6%)
1003 (61.4%)
Race/ethnicity
3190
0.6896
White
1939 (60.8%)
950 (61.1%)
989 (60.5%)
Black
524 (16.4%)
260 (16.7%)
264 (16.2%)
Hispanic
440 (13.8%)
203 (13.1%)
237 (14.5%)
Others
287 (9.0%)
142 (9.1%)
145 (8.9%)
LA-E visit
Age
3190
72.7 (6.2)
72.7 (6.3)
72.7 (6.1)
0.7424
BMI
3019
33.2 (6.2)
33.6 (6.2)
32.9 (6.1)
0.0012
HbA1c%
2665
7.5 (1.5)
7.5 (1.5)
7.5 (1.4)
0.5779
PHQ-9
3052
2.7 (3.3)
2.8 (3.4)
2.6 (3.2)
0.1786
PHQ-9 = 0
3052
937 (30.7%)
458 (30.8%)
479 (30.6%)
0.9079
SF-36 general health
3156
2.9 (0.8)
2.9 (0.8)
2.9 (0.8)
0.4558
PAT-D
3157
1.5 (0.5)
1.5 (0.5)
1.5 (0.5)
0.5800
PAT-D = 1
3157
419 (13.3%)
212 (13.8%)
207 (12.8%)
0.4165
400 m walk time (min)
2632
6.7 (1.9)
6.8 (2.0)
6.7 (1.9)
0.6073
Gait speed test (sec)
2949
4.93 (1.67)
5.00 (1.71)
4.85 (1.62)
0.0168
Grip strength (right hand)
2702
23.9 (9.4)
23.8 (9.5)
24.0 (9.3)
0.5225
Taking antidepressants
2822
699 (24.8%)
337 (24.5%)
362 (25.0%)
0.7546
Taking any diabetes med
3067
2814 (91.8%)
1380 (92.3%)
1434 (91.2%)
0.2744
Biguanide
2967
2063 (69.5%)
1008 (69.5%)
1055 (69.6%)
0.9868
Insulin
2894
1344 (46.4%)
704 (49.5%)
640 (43.5%)
0.0010
Sulfonylurea
2863
979 (34.2%)
490 (35.1%)
489 (33.4%)
0.3460
TZD
2758
198 (7.2%)
94 (7.0%)
104 (7.4%)
0.6900
Loneliness
3190
3.86 (1.38)
3.90 (1.42)
3.82 (1.34)
0.1164
Values are given as mean (SD) or N (%)