Granulocyte-colony stimulating factor-producing esophageal carcinosarcoma: A case report

Esophagus (Impact Factor: 0.74). 10/2007; 4(3):117-120. DOI: 10.1007/s10388-007-0113-0


An 80-year-old man presented at our hospital with chest oppression and vomiting. An endoscopic examination revealed a tumor
in the lower portion of the esophagus, and the patient was diagnosed as possibly having esophageal carcinosarcoma based on
a histological examination of endoscopic biopsy specimens. During the initial medical examination, the patient had a high
leukocyte count and a high level of serum granulocyte-colony stimulating factor (G-CSF). Moreover, immunohistochemical examination
revealed cells that were positive for antibodies against G-CSF. Therefore, we diagnosed the patient as possibly having a G-CSF-producing
esophageal carcinosarcoma. The patient died of tumor 4 months after the initial diagnosis.

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