PET Imaging of Response and Resistance to Cancer Therapy

Chapter · December 2005with3 Reads
DOI: 10.1007/978-1-59745-035-5_5
In book: Cancer Drug Resistance, pp.105-122

    Abstract

    As cancer treatment moves towards more targeted therapy, there is an increasing need for tools to guide therapy selection
    and to evaluate response. Biochemical and molecular imaging can complement existing in vitro assay methods and is likely to
    play a key role in early drug testing and development, as well as future clinical practice. Imaging is ideally suited to assessing
    the spatial and temporal heterogeneity of cancer and to measure in vivo drug effects. This chapter highlights imaging approaches
    to guide cancer therapy, focusing on positron emission tomography and on those approaches that have undergone preliminary
    testing in patients. Examples showing how positron emission tomography imaging can be used to (1) assess the therapeutic target,
    (2) identify resistance factors, and (3) measure early response are described.

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