This paper investigates the characteristics of university-industry collaboration in a large set of research joint ventures (RJVs) established in the context of the European Framework Programmes over a period of fourteen years. The share of university-industry RJVs is found to have gradually increased. Such RJVs have tended to be relatively larger in terms of participant numbers. Universities from peripheral European regions have been rather active in the examined RJVs. Firms cooperate with Universities to exploit research synergies leading to cost savings or improvements in R&D productivity, keeping up with major technological developments, and sharing R&D cost. Firms reported that the most important benefit from such collaboration has been the positive impact on their knowledge base.