DSC study of radiostability of 1,4-dihydropyridine derivatives

ArticleinJournal of Thermal Analysis and Calorimetry 77(2):581-596 · January 2004
Impact Factor: 2.04 · DOI: 10.1023/B:JTAN.0000038996.14324.34

    Abstract

    The effect of sterilisation by irradiation has been studied for the seven most often used in medicine derivatives of 1,4-dihydropyridine
    (nifedipine, nisoldipine, nicardipine, nitrendipine, nimodipine, felodipine and amlodipine). The sterilisation was performed
    for the compounds in the solid phase with an electron beam of the energy 10 MeV, at room temperature, using the irradiation
    doses from 20 to 400 kGy. The effects of the irradiation were studied by the methods SEM, DSC, XRD and TLC. The sterilisation
    with doses 20-100 kGy was found to cause no changes in the physico-chemical properties of the compounds, while the irradiation
    with higher doses (200-400 kGy) was found to induce changes in the colour, DSC spectrum and TLC picture. As follows from the
    TLC results, the main product of radiolysis of the compounds studied was a pyridine nitrozoderivative, which indicates the
    same mechanism of decomposition as in the process of photodegradation. The results prove that the 1,4-dihydropyridine derivatives
    being highly sensitive to visible and UV radiation are generally resistant to ionising radiation and thus can be subjected
    to sterilisation by irradiation.