Age-related macular disease in a 91-year-old patient: Histologic findings
Age-related macular degeneration in the eye of a 91-year-old man was studied histologically. Typical of this disease, which manifests as death of central photoreceptors, were dystrophic changes of the retinal pigment epithelium (RPE) and neural retina. Also typical were increased drusen deposits, which accumulated between the RPE basement membrane and the inner layer of Bruch's membrane, and choroidal neovascularization. We histologically observed and demonstrated a subclinical neovascularization that fluorescein angiography did not.
- [Show abstract] [Hide abstract] ABSTRACT: Clinical and pathological examination was performed on 378 eyes from 216 patients aged 43 to 97 years. This series represented eyes in which the fundi were normal or showed various manifestations of senile macular degeneration. The eyes were divided into six groups according to the histological appearance of a linear deposit at the base of the retinal pigment cells. Groups I and II were considered to represent normal ageing, Groups III and IV the progressive development of senile macular degeneration, and Groups V and VI the end-results.0Comments 588Citations
- [Show abstract] [Hide abstract] ABSTRACT: Age-related macular degeneration is the leading cause of irreversible loss of vision in the west, accounting for up to 50% of all blind registrations. With an ageing population age-related macular degeneration will have a discernible impact on society and the NHS. This article outlines our current level of understanding of age-related macular degeneration and treatment strategies.0Comments 695Citations
- [Show abstract] [Hide abstract] ABSTRACT: Tissue obtained from the macula in 10 human eyes (53-77 years) was used for an investigation into the extracellular matrices of the retinal pigment epithelium (RPE), Bruch's membrane, and the choriocapillaris. The ultrastructural distribution of type IV collagen and laminin was documented using immunogold labelling. Labelling for type IV collagen was strongly positive in all the specimens in the basement membranes of the choriocapillaris but not that of the RPE where labelling was either weak or absent. Laminin was localised to deposits of granular material in Bruch's membrane but was absent from the basement membrane of the RPE and the choriocapillaris. Basal linear deposit, observed in three cases, demonstrated labelling for laminin but not for type IV collagen. The series was too small for correlation of these morphological changes with age.0Comments 55Citations