Age-related macular disease in a 91-year-old patient: Histologic findings

Sapienza University of Rome, Roma, Latium, Italy
Annals of Ophthalmology (Impact Factor: 0.17). 04/2012; 32(3):206-209. DOI: 10.1007/s12009-000-0056-8


Age-related macular degeneration in the eye of a 91-year-old man was studied histologically. Typical of this disease, which
manifests as death of central photoreceptors, were dystrophic changes of the retinal pigment epithelium (RPE) and neural retina.
Also typical were increased drusen deposits, which accumulated between the RPE basement membrane and the inner layer of Bruch's
membrane, and choroidal neovascularization. We histologically observed and demonstrated a subclinical neovascularization that
fluorescein angiography did not.

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