Straver, M. E. et al. The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer. Breast Cancer Res. Treat. 119, 551-558

Breast Cancer Research and Treatment (Impact Factor: 3.94). 02/2010; 119(3):551-558. DOI: 10.1007/s10549-009-0333-1
Source: PubMed


The 70-gene signature (MammaPrint™) is a prognostic tool used to guide adjuvant treatment decisions. The aim of this study
was to assess its value to predict chemosensitivity in the neoadjuvant setting. We obtained the 70-gene profile of stage II–III
patients prior to neoadjuvant chemotherapy and classified the prognosis-signatures. Pathological complete remission (pCR)
was used to measure chemosensitivity. Among 167 patients, 144 (86%) were having a poor and 23 (14%) a good prognosis-signature.
None of the good prognosis-signature patients achieved a pCR (0/23), whereas 29/144 patients (20%) in the poor prognosis-signature
group did (P=0.015). All triple-negative tumors (n=38) had a poor prognosis-signature. Within the non triple-negative subgroup, the response of the primary tumor remained
associated with the classification of the prognosis-signature (P=0.023). A pCR is unlikely to be achieved in tumors that have a good prognosis-signature. Tumors with a poor prognosis-signature
are more sensitive to chemotherapy.

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