Antiangiogenic therapy for breast cancer: current status and future perspectives

ArticleinThe Chinese-German Journal of Clinical Oncology 10(7):373-379 · July 2011
DOI: 10.1007/s10330-011-0812-9

    Abstract

    Tumor angiogenesis plays an important role in the growth, invasion and metastasis of breast cancer, therefore recently a very
    active area of breast cancer research involves the addition of antiangiogenic therapy. Numerous clinical studies for several
    antiangiogenic agents have recently been conducted in breast cancer patients and have shown clinically significant improvement
    in outcomes. This review gives a brief background to breast cancer angiogenesis, also focusing on current progress in the
    field of antiangiogenic therapy for breast cancer and issues regarding future therapeutic development.

    Key wordsbreast cancer–angiogenesis–antiangiogenic therapy–vascular endothelial growth factor (VEGF)–bevacizumab