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Suicid mit Opipramol (Insidon®)

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Abstract

A case of suicide with 100 tablets of Opipramol (Insidon, 5.0 g) is described. The patient was admitted to the hospital 12–18 hours after ingestion of the tablets. At first the patient was in a state of clear consciousness but he died later following a series of epileptic attacks. The pathological, histological and chemical findings are reported, along with the concentration of the drug in the various organs and cerebral sections.

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... Information on other antidepressant drugs originates mostly from post mortem human brain tissues after rare cases of acute suicidal intoxication. For example, the brain:plasma ratio was found to be 6.7:1 for citalopram [15] and 10:1 for opipramol [2]. However, these values probably underestimate the true ratio because the time period between intoxication and death is usually to short for the plateau levels in the brain to be reached. ...
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Der Stoffwechsel des Psychopharmakons Tofranil
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Vergleich mit Tofranil; Katamnesen
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-hydroxy-äthyl)-piperazin-dihydrochlorid
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