I fattori di crescita e gli “scaffold” biologici nella chirurgia della cuffia dei rotatori

ArticleinLO SCALPELLO-OTODI Educational 22(1):66-76 · October 2008with12 Reads
DOI: 10.1007/s11639-008-0092-5

Rotator cuff injuries are a common source of pain and an important cause of reduction of quality of life. In Italy, it is estimated that 30% of individuals over 60 years of age experience rotator cuff injuries. Despite the advances in surgical techniques, the rate of recurrent tears after surgical repair is high (up to 40%). Tendon healing forms lower quality tissue and, despite remodelling the healed tendon’s tissue never matches that of intact tendon. Due to the frequency of these injuries, as well as the rate of re-tear, it is not surprising that new and innovative strategies like tissue engineering have become more appealing. Tissue engineering strategies involve the use of scaffolds, cells, and/or bioactive factors to promote tendon regeneration via natural processes. The present paper reviews the current state of knowledge regarding regeneration of tendon’s tissue from cells with the support of scaffolds and growth factors.