Article

Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer. The RANX05Colorectal Cancer Study Group

Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region, Denmark
Annals of Surgical Oncology (Impact Factor: 3.93). 04/2012; 7(8):617-623. DOI: 10.1007/BF02725342

ABSTRACT

Background: Preoperative plasma plasminogen activator inhibitor-1 (PAI-1) is a prognostic variable in patients with colorectal cancer.
It has been suggested, however, that plasma PAI-1 is a nonspecific prognostic parameter similar to the acute-phase reactant
C-reactive protein (CRP). In the present study we analyzed the association between plasma PAI-1 and serum CRP in patients
scheduled for elective resection of colorectal cancer. In addition, the prognostic value of PAI-1 and CRP was studied in this
patient cohort.

Methods: PAI-1 and CRP were analyzed in citrated plasma and serum, respectively, obtained preoperatively from 594 patients. Patients
who required preoperative blood transfusion received SAGM blood, in which soluble PAI-1 is not present. None of the patients
received pre- or postoperative adjuvant chemotherapy, and all were followed in the outpatient clinic for at least 5 years
or until death. The association of PAI-1 and CRP, respectively, with survival was tested using the median value of PAI-1 and
the upper normal limit for CRP. Analyses were performed by inclusion of all patients, and in the subgroup of patients, who
underwent curative resection.

Results: The median follow-up period was 6.8 (5.4–7.9) years. The median value of plasma PAI-1 was 35.8 ng/ml, and values greater
than 94 nmol/L identified patients with increased CRP levels. Comparison of the molecules showed that PAI-1 was weakly correlated
with CRP (r=.26;P<.0001). Both molecules showed a Dukes independent distribution. In univariate survival analyses high levels of PAI-1 were
found associated with poor prognosis and low levels with good prognosis (P=.02, HR: 1.3). Similarly, high levels of CRP were found associated with poor prognosis and low levels with good prognosis
(P<.0001, HR: 1.9). In a multivariate statistical analysis including Dukes classification, gender, age, tumor location, perioperative
blood transfusion, PAI-1 and CRP, plasma PAI-1 was a dependent prognostic variable, while serum CRP (P<.0001; HR: 1.4; 95% CI: 1.3–1.5) was found to be a Dukes independent prognostic variable. Similar analyses, excluding patients
with Dukes’ D disease showed serum CRP to be an independent prognostic variable (P<.0001; HR: 1.3: 95% CI: 1.2–1.5).

Conclusions: This study did not show a strong correlation between plasma PAI-1 and serum CRP in patients with colorectal cancer. Serum
CRP was found to be a Dukes independent prognostic variable in this patient cohort, and was found to identify a subgroup of
curatively resected patients at risk for short survival.

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Available from: Steen Sørensen, Dec 17, 2015
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