The injection mold is a high precision tool responsible for the production of most plastic parts used everywhere. Its design is considered critically important for the quality of the product and efficient processing, as well as determinant for the economics of the entire injection molding process. However, typically, no formal engineering analysis is carried out during the mold design stage. In fact, traditionally, designers rely on their skills and intuition, following a set of general guidelines. This does not ensure that the final mold design is acceptable or the best option. At the same time, mold makers are now highly pressured to shorten both leading times and cost, as well as to accomplish higher levels of mold performance. For these reasons, it is imperative to adopt new methods and tools that allow for faster and higher integrated mold design. To that end, a new global approach, based on the integration of well-known quantitative techniques, such as Design for Six Sigma (DFSS), Structural Equation Modeling (SEM), Axiomatic Design (AD) and Multidisciplinary Design Optimization (MDO) is presented. Although some of these methods have been largely explored, individually or in combination with other methodologies, a quantitative integration of all aspects of design, in such a way that the whole process becomes logical and comprehensible, has not yet been considered. To that end, the DFSS methodology, through its IDOV roadmap, was adopted. It is based on the ICOV Yang and El-Haik proposal, establishing four stages for the design process: Identify, which aims to define customers' requirements/expectations; Design, where the creation of a product concept, and its system-level design, is performed; Optimization, in which all the detailed design, through product optimization, is handled; and finally, Validation, where all product design decisions are validated, in order to verify if the new designed entity indeed meets customer and other requirements. As a result, this approach tackles the design of an injection mold in a global and quantitative approach, starting with a full understanding of customer requirements and converting them into optimal mold solutions. In order to validate it, an integrated platform was developed, where all different analysis modules were inserted and optimized through an overseeing code system. The results attained highlight the great potential of the proposed framework to achieve mold design improvements, with consequent reduction of rework and time savings for the entire mold design process.