TH17 Cells in Organ Transplantation Rejection and Tolerance

Chapter · December 2010with25 Reads
DOI: 10.1007/978-1-4419-9371-7_17
In book: TH17 Cells in Health and Disease, pp.319-339


    The emergence of TH17 cells as a distinct subset of effector T cell has led to a revised model of the adaptive immune system. In experimental
    and clinical transplantation, the TH17-producing cytokine, interleukin (IL)-17, is evident in allograft rejection. It is conceivable that TH17 cells could play a specific role in pathogenic process of allograft rejection. This chapter summarizes the current spectrum
    of TH17 cells in transplant rejection. The tolerance and regulation of TH17 response in the allogeneic context is also discussed.