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Anaphylaktische Reaktion durch Ficus benjamina (Birkenfeige)
Abstract
Zusammenfassung Ficus benjamina (Birkenfeige) ist eine in Innenrumen weit verbreitete Zierpflanze. Allergene von Ficus benjamina sind eine bekannte Ursache von IgE-vermittelten respiratorischen Erkrankungen. Wir betreuten eine 32-jhrige Patientin, die seit 10 Jahren an perennialer Rhinokonjunktivitis litt. Beim Abstauben ihrer bis zu zwei Meter hohen Ficus-benjamina-Pflanzen entwickelte sie eine anaphylaktische Reaktion, von der sie sich folgenlos erholte. Beim Pricktest zeigte die Patientin eine ausgeprgte Reaktion auf einen Ficus-Extrakt, im Serum waren spezifische IgE-Antikrper der CAP-Klasse 6 gegen Ficus nachweisbar. Auf Provokationstests mit Ficus-Allergenen konnte unter Bercksichtigung der starken Testreaktionen in Verbindung mit der eindeutigen Anamnese verzichtet werden. Nach Entfernung der seit 17 Jahren vorhandenen Ficus-Pflanzen und grndlicher Reinigung der Wohnung sistierte die perenniale Rhinokonjunktivitis. Zustzlich fand sich bei der Patientin eine bei Ficus-Allergie hufige, als “Kreuzreaktion” zu interpretierende Sensibilisierung gegenber Naturlatex. Als bedeutsamer Allergentrger sollte Ficus benjamina weder in Wohn- noch in Arbeitsbereichen gehalten werden.
... Specifically, sapele is a tropical tree widely distributed in Africa and its wood is used in carpentry due to its durability and attractive appearance. We have found only 1 previously reported case of sensitization to sapele wood in a carpenter's son, although presenting as asthma and angioedema rather than dermatitis (9). ...
... The only case of allergic contact dermatitis from spearmint at any other site was that of a 64-yearold woman who developed vesicobullous lesions on the knee after repeated applications of compresses made with an infusion of Mentha spicata leaves (8). Carvone is one of the main constituents of spearmint oil and has been implicated as the main allergen, although in a human maximization test, carvone (1% pet.) did not sensitize (9). ...
... There have been reported anaphylactic reactions after ingestion of fresh fig (8) and to Ficus benjamina (9), which seems to share some common allergens. Our patients did not show any manifestations of such a reaction. ...
... Specifically, sapele is a tropical tree widely distributed in Africa and its wood is used in carpentry due to its durability and attractive appearance. We have found only 1 previously reported case of sensitization to sapele wood in a carpenter's son, although presenting as asthma and angioedema rather than dermatitis (9). ...
... The only case of allergic contact dermatitis from spearmint at any other site was that of a 64-yearold woman who developed vesicobullous lesions on the knee after repeated applications of compresses made with an infusion of Mentha spicata leaves (8). Carvone is one of the main constituents of spearmint oil and has been implicated as the main allergen, although in a human maximization test, carvone (1% pet.) did not sensitize (9). ...
... There have been reported anaphylactic reactions after ingestion of fresh fig (8) and to Ficus benjamina (9), which seems to share some common allergens. Our patients did not show any manifestations of such a reaction. ...
... Persons who are a latex allergy and atopic are suggested to avoid beringin (F. benjamina) (Axelsson 1995;Schenkelberger et al. 1998;Werfel et al. 2001). Queensland Government and the United States Department of Agriculture (USDA) classified kamboja merah (P. ...
The suitability assessment of the tree species in the urban parks and urban forest in Kediri City, East Java, Indonesia. Nusantara Bioscience 13: 131-139. Kediri has several urban parks and an urban forest as green open space (GOS) which have essential roles in economical, social, aesthetical, and ecological aspects. Generally, urban trees provide ecosystem services, such as carbon sequestration, stormwater attenuation, energy conservation, habitat for wildlife, air, water, and noise pollutants reduction. The present study aimed to (i) determine tree diversity in five urban parks and an urban forest on Kediri City and (ii) evaluate the suitability of tree species based on three indicators (silviculture, management, and aesthetic). This study was conducted in five urban parks and one urban forest in Kediri City. The suitability assessment was carried out through a literature review. The results showed that 29 tree species belonging to 17 families were found in the study sites, with the family Fabaceae being the most dominant one with five species. The number of exotic tree species (17) was higher than that of the native ones (12). The suitability assessment results showed that 21 tree species had a high score of 39-44, and only eight urban tree species had a medium score of 36-38. The urban parks and urban forests in Kediri were managed for the conservation of germplasm, recreation, and protection. The shapes were clumped and line. This study will contribute information to be used as guidance for urban tree management and policy framework.
... comosa) (Moraceae), commonly known as kabra, is a moderate sized, evergreen epiphytic tree (Brandis, 1971). Ficus benjamina is used in folk medicine for the treatment of certain skin and respiratory disorders (Dhar, Dhawan, Mehrotra, & Ray, 1968;Dhawan, Patnaik, Rastogi, Singh, & Tandon, 1977) and the fruit extract of F. benjamina is also known to possess antitumour activity and significant antibacterial activity (Axelesson, Johansson, Lavsson, & Zeltu Strom, 1990;Diez-Gomez, Quirce, Avagoneses, & Cuevas, 1998;Mousa et al., 1994;Werfel, Rue¨ff, & Przybilla, 2001). Medicinal importance of this plant encourages us to carry out a comprehensive investigation of the leaves of F. benjamina (var. ...
The benzene extract of the leaves of Ficus benjamina (variety comosa) afforded a new triterpene, named serrat-3-one (Fc-2), along with the known phytoconstituents pentacontanyl decanoate (Fc-1), friedelin and beta-sitosterol. Their structures were established on the basis of chemical and physical evidence (IR, (1)H NMR, (13)C NMR and MS). The aqueous and alcoholic extracts of leaves of F. bejamina showed significant antinociceptive activity in an analgesiometer test.
Ficus benjamina is a plant very often used for indoor decorations that can generate allergies, e.g. rhinoconjunctivitis, urticaria and Quinke's edema as well as anaphylactic reactions. We report the case of a patient with hypersensitivity to Ficus benjamina without cross-reactivity to Natural Rubber Latex (NRL) or several fruits, like mango, banana and spinach, but with cross-reactivity to fig. The hypersensitivity to Ficus benjamina was investigated by means of the prick test, the determination of specific IgE antibodies, the cellular antigen stimulation test (CAST) and Westernblots. A self-produced Ficus benjamina extract, a Ficus benjamina extract from Allergopharma, extract of Hevea brasiliensis and extracts of several fruits were used in the prick tests as well as in the CAP and CAST experiments. CAP inhibition assays were carried out to study a suspected cross-reactivity of Ficus benjamina to NRL and several fruits, respectively. The hypersensitivity to Ficus benjamina was clearly demonstrated. Inhibition assay showed the inhibition of the specific IgE antibody up to 95%, and 82% by the self-produced Ficus benjamina extract and the commercial Ficus benjamina, respectively. Neither sensitization nor cross-reactivity to Hevea brasiliensis and several fruit proteins could be found, apart from cross-reactivity to fig. In our patient, an isolated type I hypersensitivity to Ficus benjamina with cross-reactivity to fig could be found, but without cross-reactivity to NRL. The Ficus benjamina protein seems to become an important indoor allergen with increasing significance.
Examination of an active extract of the fruit of Ficus benjamina var. nuda (Miq.) Barrett has led to the isolation of six new isoflavones and two coumarano-chroman-4-ones, along with fifteen known compounds. The structures of the eight new compounds were elucidated on the basis of extensive NMR experiments and mass spectrometric measurements. The inhibitory activity of the compounds on the proteolytic cleavage of amyloid precursor protein by the aspartic protease BACE1 was evaluated. Both coumarano-chroma-4-ones and some isoflavones showed moderate activity in this assay.
Bei der am hufigsten in Deutschland angezeigten Berufskrankheit handelt es sich um die BK-Nummer 5101, schwere oder wiederholt rckfllige Hautkrankheiten, die zur Unterlassung aller Ttigkeiten gezwungen haben, die fr die Entstehung, die Verschlimmerung oder das Wiederaufleben der Krankheit urschlich waren oder sein knnen. Der berwiegende Teil der Berufsdermatosen geht zu Lasten irritativer oder allergischer Kontaktekzeme. Berufsbedingte Soforttypallergien, die sich als Kontakturtikariasyndrom manifestieren, sind vergleichsweise selten, beinhalten jedoch das Risiko schwerer Systembeteiligung. Die klinische Symptomatik, die Arbeitsplatz bezogene Exposition und Gefhrdung durch berufsrelevante Typ-I-Allergene sind dargestellt.In Germany the most frequent initial report of occupational disease is due to occupational skin diseases (Berufskrankheitenanzeige nach Nr. 5101 der Berufskrankheitenverordnung) defined as severe or recurrent skin diseases that force the discontinuation of any activity that causes or that could be causing the development, the worsening, or the recurrence of the skin disease. The majority of these occupational skin diseases consists of irritant and allergic contact dermatitis. In contrast, work place- related Type I allergy (contact urticaria syndrome) is less frequent, but carries the risk of systemic reactions. The clinical manifestations and pattern of exposure to Type I allergens in the work place are described.
Ornamental Ficus benjamina (FB) has been recognized as a new indoor allergen. Little is known about the prevalence in moderately exposed subjects and the proposed association with fruit and Hevea latex hypersensitivity.
To study the prevalence of FB sensitization and the relationship with Hevea latex allergy, to identify cross-reacting fruits, and to characterize the responsible allergens.
A skin prick test solution prepared from FB latex (200 microg/mL) was included in our routine screening programme for suspect inhalant allergy. Patients reacting with the FB extract were further skin tested with exotic fruits by the prick-to-prick method. Inhibition of fig and FB CAP by FB latex, fig (Ficus carica), kiwi, the thiolproteases ficin and papain, Hevea latex and rHev b 6.02 (hevein) was performed in selected patients.
Of 2662 patients with a positive skin test to any aeroallergen, 66 (2.5%) reacted with FB. Ten patients showed isolated sensitization to FB. Although FB-positive subjects were more often co-sensitized to Hevea latex than FB-negative (10.6% vs 3.8%, P< 0.01), nearly 90% tested negative for Hevea latex. Sensitization to FB was specifically associated with positive skin tests to fresh fig (83%), dried fig (37%), kiwi fruit (28%), papaya (22%), avocado (19%), banana (15%), and pineapple (10%) (n = 54). Clinical reactions were reported mainly from fresh and dried fig and kiwi (47%, 60%, and 64%, respectively, of skin test-positive patients), including seven patients with systemic reactions (urticaria, angiooedema, asthma). CAP to fig in 11 patients with clinical fruit allergy was inhibited on average by 87% by FB latex, 89% by fresh fig, 80% by dried fig, 38% by kiwi (100 microg/mL each), and by 59% and 44% by ficin and papain (50 microg/mL), respectively. No inhibition was obtained with Hevea latex and rHev b 6.02. CAP to FB was inhibited on average by 95% by FB, 60% by fresh fig, 41% by ficin, 29% by papain, and less than 7% by rubber latex allergens.
Sensitization to FB latex is found in 2.5% of atopic individuals and mostly occurs independently of Hevea latex allergy. Sensitization is commonly associated with allergic reactions to figs and other tropical fruits ('Ficus-fruit syndrome'). This cross-reactivity is mediated at least in part by thiolproteases.
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