Eales’ Disease

Chapter · January 2006with28 Reads
DOI: 10.1007/978-1-59745-047-8_8
In book: Ocular Angiogenesis, pp.149-159
Eales’ disease was first described by Henry Eales in 1880 (1). The patient presents with retinal perivasculitis predominantly affecting the peripheral retina (inflammatory stage), then sclerosis of retinal veins indicating retinal ischemia (ischemic stage), and finally retinal or optic disk neovascularization, recurrent vitreous hemorrhage with or without retinal detachment (proliferative stage) (2–4).
  • [Show abstract] [Hide abstract] ABSTRACT: Thirty-two patients with documented Eales' disease who have been followed-up at Johns Hopkins Hospital for periods of as long as 37 years were investigated. The previously reported association of Eales' disease with tuberculoprotein hypersensitivity was confirmed in 10 of 21 patients tested. For the first time, associated vestibuloauditory dysfunction is described. The previously reported association with multiple sclerosis was not confirmed. Eales' disease is a specific vasculopathy that can affect both the retinal and vestibuloauditory circulations. Patients with suspected Eales' disease should also be examined to rule out other diseases such as diabetes, sarcoidosis, and connective tissue diseases including systemic lupus erythematosus. This can be done by obtaining such tests as fasting blood glucose, chest radiograph, erythrocyte sedimentation rate, antinuclear antibody, rheumatoid factor, and LE cell preparation. Tuberculoprotein sensitivity status should be ascertained and active tuberculosis should be ruled out. The patient should be questioned regarding hearing or balance problems, and if a history suggestive of abnormalities is elicited, referral for vestibuloauditory function testing should be made.
    Article · Oct 1983
  • [Show abstract] [Hide abstract] ABSTRACT: Repeated vitreous haemorrhage is a common occurrence in Eales disease. 25 eyes of unresolving vitreous haemorrhage were subjected to pars plana vitrectomy. 18 eyes improved to 1/60 or better. Vitreous rebleed was the commonest problem encountered. We discuss our experience, complications and limitations.
    Article · Apr 1992
  • Article · Feb 1965
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