Complete pathological response of colorectal liver metastases after chemotherapy and bevacizumab treatment: A case report

ArticleinTargeted Oncology 3(4):253-258 · October 2008with5 Reads
Impact Factor: 4.00 · DOI: 10.1007/s11523-008-0094-5


    The vast majority of colorectal cancer patients who present with liver metastases are not initially candidates for hepatic
    resection. Although the combination of systemic chemotherapy and liver surgery can convert a significant proportion of patients
    from a palliative situation to a potentially curative situation, the majority of initially unresectable liver metastases do
    not respond sufficiently to initial chemotherapy to become resectable. More recently the addition of biologic agents (bevacizumab
    or cetuximab) to cytotoxic chemotherapy has increased the rate of tumor response, suggesting that the addition of these agents
    could improve resectability rate. Here we report the clinical case of a complete pathological response (pCR) in a 67-year-old
    male affected by metastatic colorectal cancer, with initially unresectable liver metastases, after treatment with chemotherapy
    and bevacizumab.