Therapeutische Hypothermie

Notfall (Impact Factor: 0.47). 11/2008; 11(7):453-458. DOI: 10.1007/s10049-008-1070-4


Therapeutic mild hypothermia (32–34°C) is one of the most efficacious therapies to prevent neurologic damage after cardiac arrest. The guidelines of the European Resuscitation Council recommend that “unconscious adult patients with spontaneous circulation after out-of-hospital cardiac arrest should be cooled to 32–34°C for 12–24 hours when the initial rhythm was ventricular fibrillation (VF). Such cooling may also be beneficial for other rhythms or in-hospital cardiac arrest.” Observational studies show that patients in cardiogenic shock are not compromised by therapeutic hypothermia, and that even in these patients neurologic outcome is better when they receive therapeutic hypothermia. Reaching the target temperature more quickly may improve the effect of the therapy. Further randomised studies are necessary to elucidate important questions, such as the exact target temperature, length of therapy and rewarming rates in order to further improve the effect of therapeutic hypothermia.

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    ABSTRACT: Background While mild therapeutic hypothermia (MTH) is recommended to decrease mortality and neurological deficits after cardiopulmonary resuscitation, long-term outcome data are scarce. Patients and methods The outcome and quality of life of all patients with the ICD-10 diagnosis I46.0 and ICU treatment with MTH between 1 December 2002 and 31 December 2007 were assessed with a questionnaire that was sent to all patients discharged alive. Results Of 83 patients, 38 (46%) survived to hospital discharge. A total of 24 of the original 38 questionnaires were returned: 19 patients reported no or only minor restrictions of quality of life (e.g., dialysis). Five patients had deceased. Conclusion All long-term survivors report a normal or only minor restricted quality of life.
    No preview · Article · Feb 2011 · Intensivmedizin + Notfallmedizin