Biological importance of imidazole nucleus in the new millennium

Medicinal Chemistry Research (Impact Factor: 1.4). 11/2011; 20(8):1119-1140. DOI: 10.1007/s00044-010-9472-5


Imidazole nucleus is a constituent of many bioactive heterocyclic compounds that are of wide interest because of their diverse
biological and clinical applications. This created interest in researchers to synthesize variety of imidazole derivatives
and to screen them for their various biological activities viz. anti-cancer, anti-viral, antiHIV, anti-protozoal, anti-mycobacterial,
anti-inflammatory, analgesic, anxiolytic, as well anti-diabetic activities.

KeywordsImidazole–Anti-cancer–Analgesic–Anti-bacterial activity

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    • "Through this study, we have discovered some novel imidazo[4,5-b]pyridine derivatives showing potent activity against both antiglycation and antioxidation activities. Our research was inspired by the fact that compounds having imidazole possess versatile biological properties and easily interact with the nature (Narasimhan et al., 2011). Compounds having fused imidazole ring, had been reported for various activities such as urease inhibition (Saify et al., 2014), antibacterial (Vijesh et al., 2011), anticancer (Yang et al., 2012), antitubecular (Lee et al., 2011) and analgesics (Uc¸ucu et al., 2001) activities . "
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