Medicinal uses of inorganic compounds - 1
04/2006; 11(4):75-89. DOI: 10.1007/BF02835732
In this two part article, we describe some aspects of inorganic drugs that bridge the areas of inorganic chemistry and medicine.
In this first part, we describe the therapeutic potential of inorganic compounds as neurological, anticancer, antimicrobial,
antiulcer, antiviral, anti-inflammatory, cardio vascular and insulin-mimetic agents.
Available from: Ashu Mittal
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ABSTRACT: A series of metal complexes of Cu(II), Zn(II) and Hg(II) having the general composition [M(L) 2 X 2 ] [where L = thiourea; M = Cu(II), Zn(II) or Hg(II) and X = Cl – , NO 3 – or CH 3 COO – ] have been synthesized. All the metal complexes were characterized by elemental chemical analysis, molar conductance, magnetic susceptibility measurements and IR spectroscopy. Cu(II) complexes were additionally characterized by electronic and EPR spectral studies. The IR spectral data suggests the involvement of sulphur atom in coordination to the central metal ion. On the basis of spectral studies square planar geometry has been assigned to Cu(II) complexes except [Cu(L) 2 (CH 3 COO –) 2 ] which exhibits six coordinated tetragonal geometry. However, all Zn(II) and Hg(II) complexes exhibited tetrahedral geometry. Furthermore, to achieve a better pharmacological profile, thiourea and its metal com-plexes were screened for in vitro antimicrobial activity against the human pathogenic bacteria Staphylococcus aureus, Staphylococ-cus epidermides, Escherichia coli and Pseudomonas aeruginosa and against the fungi Candida albicans and Aspergillus niger. Thiourea and its metal complexes were also screened for in vivo anti-inflammatory activity. Thiourea did not exhibit antibacterial activity but showed antifungal activity. However, it is important to note that the Cu(II), Zn(II) and Hg(II) complexes of thiourea exhibited antibacterial and enhanced antifungal activity. Neither thiourea nor its metal complexes exhibited anti-inflammatory activity. KEYWORDS Thiourea complexes, spectroscopy, antibacterial activity, antifungal activity, anti-inflammatory activity.
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