Release of cationic drugs from loaded clay minerals

ArticleinColloid and Polymer Science 279(12):1177-1182 · November 2001with14 Reads
Impact Factor: 1.87 · DOI: 10.1007/s003960100527

    Abstract

    The adsorption of promethazine chloride [10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride
    (1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption
    of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0 ± 0.1) at the temperature
    of the human body (37 ± 0.5 °C). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier
    transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage,
    exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution
    rate.