Comparison of octenidine dihydrochloride (Octenisept®), polihexanide (Prontosan®) and povidon iodine (Betadine®) for topical antibacterial effects in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats

Central European Journal of Medicine (Impact Factor: 0.15). 12/2008; 3(4):417-421. DOI: 10.2478/s11536-008-0042-x


Pseudomonas aeruginosa is one of the most frequently isolated organisms from infected burn wounds and a significant cause of nosocomial infection
and septic mortality among burn patients. In this animal study, three antiseptic agents which were Octenidine dihydrochloride
(Octenisept®, Schülke & Mayr, Norderstedt, Germany), polyhexanide (Prontosan®, B. Braun, Melsungen AG, Germany) and povidon
iodine (Betadine, Purdue Pharma L.P, Stamford, USA) were compared to assess the antiseptic effect of their applications on
experimental burn wounds in in rats contaiminated with P. aeruginosa. All treatment modalities were effective against P. aeruginosa because there were significant differences between treatment groups and control groups. The mean eschar concentrations were
not different between polyhexanide and povidon iodine groups, but there were significant differences between the octenidine
dihydrochloride group and the other treatment groups, indicating that the Octenidine dihydrochloride significantly eliminated
P. aeruginosa more effectively in the tissues compared to the to other agents. All treatment modalities were sufficient to prevent the
P. aeruginosa invasion into the muscle and to cause systemic infection. In conclusion, Octenidine dihydrochloride is the most effective
antiseptic agent in the treatment of the P. aeruginosa-contaminated burn wounds; Octenidine dihydrochloride can be considered as a treatment choice because of its peculiar ability
of limit the frequency of replacing wound dressings.

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    • "If there is an open wound on the finger, this should be cleaned and washed with saline solution, and any foreign bodies should be removed. The skin should also be cleaned with povidone iodine [9]. Tetanus prophylaxis in patients with open wounds should be performed according to the vaccination history of the patient [10] [11]. "
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    ABSTRACT: Various removal techniques for rings trapped on the finger have been described in the current literature. However, despite this being a frequently encountered situation in emergency departments, there is no comprehensive algorithm to manage and follow these patients in the current literature. The purposes of this study were to describe the most commonly used ring removal techniques and to establish an algorithm for the removal of rings trapped on fingers. We performed a comprehensive literature search in several databases to identify all articles, case reports, letters, and book chapters that focus on ring removal techniques in English language from 1960 to the present. There are 2 methods of removal: (1) noncutting techniques in which the rings can be removed without breaking the integrity of the ring and (2) various ring-cutting equipments and tools. All these techniques are classified into distinct groups and described in detail with illustrations. Furthermore, an algorithm for handling such patients is established according to case-based patient care. Following an algorithm for the removal of trapped rings on the finger will be useful for patients and emergency physicians. It will also prevent possible complications and will save time.
    Full-text · Article · Sep 2013 · The American journal of emergency medicine
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    • "Different studies showed that octenidine dihydrochlorid has strong antimicrobial effect against many gram-negative and positive agents and has a low risk of developing resistance [11,14–17]. Uygur et al. [11], have reported that octenidine dihydrochloride is the most effective agent in the treatment of Pseudomonas aeruginosa contaminated burn wound in vivo. "
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